Phenylalanyl-histidine
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| Category | Others |
| Catalog number | BBF-05143 |
| CAS | 33367-37-2 |
| Molecular Weight | 302.33 |
| Molecular Formula | C15H18N4O3 |
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Description
Phenylalanylhistidine is a dipeptide composed of phenylalanine and histidine.
Specification
| Synonyms | Phe-his; L-phenylalanyl-L-histidine |
| Sequence | H-Phe-His-OH |
| IUPAC Name | (2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid |
| Canonical SMILES | C1=CC=C(C=C1)CC(C(=O)NC(CC2=CN=CN2)C(=O)O)N |
| InChI | InChI=1S/C15H18N4O3/c16-12(6-10-4-2-1-3-5-10)14(20)19-13(15(21)22)7-11-8-17-9-18-11/h1-5,8-9,12-13H,6-7,16H2,(H,17,18)(H,19,20)(H,21,22)/t12-,13-/m0/s1 |
| InChI Key | OHUXOEXBXPZKPT-STQMWFEESA-N |
Properties
| Boiling Point | 693.4±55.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. The amino acid composition of hypertensin II and its biochemical relationship to hypertensin I
K E LENTZ, L T SKEGGS Jr, K R WOODS, J R KAHN, N P SHUMWAY J Exp Med. 1956 Aug 1;104(2):183-91. doi: 10.1084/jem.104.2.183.
Preparations of hypertensin II, obtained from the treatment of hypertensin I by the action of the hypertensin converting enzyme of plasma and purified by countercurrent distribution, were quantitatively analyzed for their amino acid content. Chromatography on ion exchange columns showed the presence of equimolar amounts of aspartic acid, proline, valine, isoleucine, tyrosine, phenylalanine, histidine, and arginine. Hypertensin I was found to contain one mole of leucine and one mole of histidine in addition to the amino acids of hypertensin II. These two amino acids were isolated from the conversion products of hypertensin I and identified as the peptide histidylleucine. Carboxypeptidase digestion of hypertensin I showed the carboxyl terminal sequence of amino acids to be residue-phenylalanyl-histidylleucine. Similar studies of hypertensin II demonstrated residue-phenylalanine. It was concluded that the conversion of hypertensin I by the plasma hypertensin converting enzyme involved hydrolysis of the phenylalanyl-histidine bond to form hypertensin II and histidylleucine. The further removal by carboxypeptidase of phenylalanine from hypertensin II destroyed all of the vasoconstrictor activity.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
