Phomopsin A
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Category | Mycotoxins |
Catalog number | BBF-04269 |
CAS | 64925-80-0 |
Molecular Weight | 789.23 |
Molecular Formula | C36H45ClN6O12 |
Purity | >98% by HPLC |
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Capabilities & Facilities
Fermentation Lab
4 R&D and scale-up labs
2 Preparative purification labs
Fermentation Plant
Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
It is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids. It is a potent mycotoxin produced by the fungus, phomopsis leptostromiformis. It is an important bioprobe for understanding cellular structural proteins. It selectively binds to the dimeric tubulin at the overlap of vinblastine and maytansine, inhibits the formation of the microtubule spindle to block cell division.
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Synonyms | 2-Oxa-5,8-diazabicyclo[10.3.1]hexadecane, cyclic peptide deriv.; (2E)-(βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-aspartic acid, cyclic (15→3)-ether; NSC 381839; PMSA; Phomopsin |
Storage | Store at -20°C under inert atmosphere |
IUPAC Name | (E)-2-[[(E)-2-[[(2S)-1-[(3R,4R,7S,10S,11S)-14-chloro-3-ethyl-11,15-dihydroxy-3-methyl-10-(methylamino)-6,9-dioxo-7-prop-1-en-2-yl-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-4-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methylpent-2-enoyl]amino]but-2-enedioic acid |
Canonical SMILES | CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C |
InChI | InChI=1S/C36H45ClN6O12/c1-8-17(5)25(32(50)39-20(35(53)54)15-23(44)45)41-30(48)21-11-10-12-43(21)34(52)29-36(6,9-2)55-22-14-18(13-19(37)28(22)47)27(46)26(38-7)33(51)40-24(16(3)4)31(49)42-29/h10-11,13-15,21,24,26-27,29,38,46-47H,3,8-9,12H2,1-2,4-7H3,(H,39,50)(H,40,51)(H,41,48)(H,42,49)(H,44,45)(H,53,54)/b20-15+,25-17+/t21-,24-,26-,27-,29-,36+/m0/s1 |
InChI Key | FAFRRYBYQKPKSY-MSBSFVTFSA-N |
Source | Phomposis leptostromiformis |
Appearance | White Solid |
Boiling Point | 1144.6±65.0°C (Predicted) |
Melting Point | 205°C (dec.) |
Density | 1.45±0.1 g/cm3 (Predicted) |
Solubility | Slightly soluble in DMSO, Methanol |
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
