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Plactin B

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Category Others
Catalog number BBF-02028
CAS
Molecular Weight 644.80
Molecular Formula C32H52N8O6

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Product Description

Plactin B is a cyclic pentapeptide physiologically active substance produced by the fungus F165. It can promote the dissolution of fibrinolytic protein.

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Synonyms Plastin B
IUPAC Name 2-[3-[(2R,5R,8S,11R,14S)-14-[(4-hydroxyphenyl)methyl]-8,11-bis(2-methylpropyl)-3,6,9,12,15-pentaoxo-5-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
Canonical SMILES CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(C)C)C(C)C)CCCN=C(N)N)CC2=CC=C(C=C2)O
InChI InChI=1S/C32H52N8O6/c1-17(2)14-23-28(43)38-25(16-20-9-11-21(41)12-10-20)30(45)36-22(8-7-13-35-32(33)34)27(42)40-26(19(5)6)31(46)39-24(15-18(3)4)29(44)37-23/h9-12,17-19,22-26,41H,7-8,13-16H2,1-6H3,(H,36,45)(H,37,44)(H,38,43)(H,39,46)(H,40,42)(H4,33,34,35)/t22-,23-,24+,25+,26-/m1/s1
InChI Key JKGLILYBNUKSGI-PUHDZGQXSA-N
Appearance White Powder
Density 1.3±0.1 g/cm3
1. Isolation of plactins A, B, C and D, novel cyclic pentapeptides that stimulate cellular fibrinolytic activity
T Inoue, K Hasumi, T Kuniyasu, A Endo J Antibiot (Tokyo). 1996 Jan;49(1):45-9. doi: 10.7164/antibiotics.49.45.
Four novel cyclic pentapeptides, designated plactins A, B, C and D, were isolated by solvent extraction and reverse-phase HPLC from mycelium of a fungal strain F165 that belongs to the order of Agonomycetales. By a combination of chemical and spectroscopic analyses and chemical synthesis, the structures of plactins A, B, C and D were determined to be cyclo(-D-Val-L-Leu-D-alloIle-L-Try-D-Arg-), cyclo(-D-Val-L-Leu-D-Leu-L-Tyr-D-Arg-), cyclo(-D-Val-L-Leu-D-alloIle-L-Phe-D-Arg-) and cyclo(-D-Val-L-Leu-D-Leu-L-Phe-D-Arg-), respectively. Plactins stimulated U937 cell-mediated degradation of 125I-fibrin plates by 50% at a concentration of 7.5 approximately 32 microM.
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