Pluracidomycin C1
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02034 |
| CAS | 82138-66-7 |
| Molecular Weight | 371.34 |
| Molecular Formula | C10H13NO10S2 |
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Description
Pluracidomycin C1 is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase.
Specification
| Synonyms | Pluracidomycin C |
| IUPAC Name | (5R,6R)-3-(dihydroxymethylsulfinyl)-7-oxo-6-[(1S)-1-sulfooxyethyl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Canonical SMILES | CC(C1C2CC(=C(N2C1=O)C(=O)O)S(=O)C(O)O)OS(=O)(=O)O |
| InChI | InChI=1S/C10H13NO10S2/c1-3(21-23(18,19)20)6-4-2-5(22(17)10(15)16)7(9(13)14)11(4)8(6)12/h3-4,6,10,15-16H,2H2,1H3,(H,13,14)(H,18,19,20)/t3-,4+,6-,22?/m0/s1 |
| InChI Key | PEGYZRANCYTAHN-MUJZCJMNSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
Reference Reading
1. Therapeutic effect of SF-2103A, a novel carbapenem antibiotic, in combination with cefotaxime, cefoperazone and other cephalosporins
T Yoshida, Y Kazuno, T Shomura, S Murata, S Inouye, T Ito J Antibiot (Tokyo). 1986 Jul;39(7):956-65. doi: 10.7164/antibiotics.39.956.
Combinations of SF-2103A with cefotaxime, cefoperazone or cefazolin showed synergistic efficacy at a wide range of combination ratios against experimental infection in mice due to Proteus vulgaris GN76/C-1, producing type Ic cephalosporinase, Escherichia coli No. 29/36 RGN823, producing type IIIa (TEM-2) penicillinase and E. coli GN206, producing type Ib cephalosporinase. These effects by SF-2103A were greater than those seen with sulbactam. The in vitro and in vivo synergistic activities were roughly correlated. Potent in vivo activity of SF-2103A was related to good pharmacokinetic properties, with blood half-life of 30 minutes and urinary recovery of 55.2% after parenteral administration to rats. Furthermore, SF-2103A was stable to rat kidney homogenate. The high stability of SF-2103A in aqueous and biological media was correlated with the sulfonate group at C-3.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
