Povidone-iodine
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Bioactive by-products |
| Catalog number | BBF-04007 |
| CAS | 25655-41-8 |
| Molecular Formula | (C6H9NO)n.xI |
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Description
Povidone-iodine can be used as a topical preservative. It has activity against Gram-positive and Gram-negative bacteria, fungi, parasites, viruses and yeast.
Specification
| Synonyms | Betadine; Isodine; PVP Iodine |
| Storage | Store at -20°C |
| IUPAC Name | 1-ethenylpyrrolidin-2-one;molecular iodine |
| Canonical SMILES | C=CN1CCCC1=O.II |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2; |
| InChI Key | CPKVUHPKYQGHMW-UHFFFAOYSA-N |
Properties
| Appearance | Red-brown Crystalline Powder |
| Application | Use to clean contaminated wounds and for pre-operative preparation of the skin; Used as a suspending agent, dispersing agent, and vehicle for pharmaceuticals, as a blood volume expander, topical antiseptic, and for infections of the skin and mucous membranes; The iodine can be radiolabeled for research applications. |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; Fungi; Viruses; parasites; yeast |
| Boiling Point | 217.6°C at 760 mmHg |
| Melting Point | 300°C |
| Flash Point | 93.9°C |
| Solubility | Soluble in DMSO, Water |
| LogP | 2.46160 |
Reference Reading
1.Effect of vaginal cleansing on postoperative factors in elective caesarean sections: a prospective, randomised controlled trial.
Göymen A1, Şimşek Y2, Özdurak Hİ1, Özkaplan ŞE1, Akpak YK3, Özdamar Ö4, Oral S5. J Matern Fetal Neonatal Med. 2016 Apr 6:1-16. [Epub ahead of print]
OBJECTIVE: To assess the effect of povidone iodine versus benzalkonium chloride, which were applied preoperatively for vaginal disinfection in caesarean sections, on postoperative factors.
2.Hamstring graft bacterial contamination during anterior cruciate ligament reconstruction: clinical and microbiological study.
Badran MA1,2, Moemen DM3,4. Int Orthop. 2016 Mar 29. [Epub ahead of print]
PURPOSE: Autograft preparation for anterior cruciate ligament (ACL) reconstruction has a potential for graft contamination. The purpose of this study was to evaluate the possibility of bacterial contamination of hamstring autograft during preparation and when dropped onto the operating room floor and methods of graft decontamination.
3.Antibiotics and antiseptics for pressure ulcers.
Norman G1, Dumville JC, Moore ZE, Tanner J, Christie J, Goto S. Cochrane Database Syst Rev. 2016 Apr 4;4:CD011586. [Epub ahead of print]
BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. A range of treatments with antimicrobial properties, including impregnated dressings, are widely used in the treatment of pressure ulcers. A clear and current overview is required to facilitate decision making regarding use of antiseptic or antibiotic therapies in the treatment of pressure ulcers. This review is one of a suite of Cochrane reviews investigating the use of antiseptics and antibiotics in different types of wounds. It also forms part of a suite of reviews investigating the use of different types of dressings and topical treatments in the treatment of pressure ulcers.
4.Does chlorhexidine and povidone-iodine preoperative antisepsis reduce surgical site infection in cranial neurosurgery?
Davies BM1, Patel HC1. Ann R Coll Surg Engl. 2016 Apr 8:1-4. [Epub ahead of print]
Introduction Surgical site infection (SSI) is a significant cause of postoperative morbidity and mortality. Effective preoperative antisepsis is a recognised prophylactic, with commonly used agents including chlorhexidine (CHG) and povidone-iodine (PVI). However, there is emerging evidence to suggest an additional benefit when they are used in combination. Methods We analysed data from our prospective SSI database on patients undergoing clean cranial neurosurgery between October 2011 and April 2014. We compared the case-mix adjusted odds of developing a SSI in patients undergoing skin preparation with CGH or PVI alone or in combination. Results SSIs were detected in 2.6% of 1146 cases. Antisepsis with PVI alone was performed in 654 (57%) procedures, while 276 (24%) had CHG alone and 216 (19%) CHG and PVI together. SSIs were associated with longer operating time (p<0.001) and younger age (p=0.03). Surgery type (p<0.001) and length of operation (p<0.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
