PS-7
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03354 |
| CAS | 72615-18-0 |
| Molecular Weight | 296.34 |
| Molecular Formula | C13H16N2O4S |
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Description
PS-7 is a beta-lactam antibiotic that can be isolated from Streptomyces cremeus subsp. auratilis, Str. fulvoviridis A-933, Str. olivaceus and Str. flavo-griseus NRRL 8139. It is effective against gram-positive and gram-negative bacteria.
Specification
| Synonyms | PS 7; PS7; Antibiotic PS 7 |
| IUPAC Name | (5R,6R)-3-[(E)-2-acetamidoethenyl]sulfanyl-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Canonical SMILES | CCC1C2CC(=C(N2C1=O)C(=O)O)SC=CNC(=O)C |
| InChI | InChI=1S/C13H16N2O4S/c1-3-8-9-6-10(20-5-4-14-7(2)16)11(13(18)19)15(9)12(8)17/h4-5,8-9H,3,6H2,1-2H3,(H,14,16)(H,18,19)/b5-4+/t8-,9-/m1/s1 |
| InChI Key | PQZKMTPCUYSWBM-HOMPQPGZSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Melting Point | 160°C (dec.) |
Reference Reading
1. Intravenous Lidocaine for Rib Fractures: Effect on Pain Control and Outcome
Sarah King, Lou Smith, Christopher Harper, Zachary Beam, Eric Heidel, Genevieve Carico, Kelsey Wahler, Brian Daley Am Surg. 2022 Apr;88(4):734-739. doi: 10.1177/00031348211050838. Epub 2021 Nov 3.
Background: Multimodal analgesia in rib fractures (RFs) is designed to maximize pain control while minimizing narcotics. Prior research with intravenous lidocaine (IVL) efficacy produced conflicting results. We hypothesized IVL infusion reduces opioid utilization and pain scores. Methods: A retrospective review of RF patients at an ACS-verified Level I trauma center from April 2018 to 2/2020 was conducted. Patients (pts) stratified as receiving IVL vs no IVL. Initial lidocaine dose: 1 mg/kg/hr with a maximum of 3 mg/kg/hr. Duration of infusion: 48 h. Pain quantified by the Stanford Pain Score system (PS). Bivariate and multivariate analyses of variables were performed on SPSS, version 21 (IBM Corp). Results: 414 pts met inclusion criteria: 254 males and 160 females. The average age for the non-IVL = 67.4 ± 15.2 years vs IVL = 58.3 ± 17.1 years (P < .001). There were no statistically significant differences between groups for ISS, PS for initial 48 h, and ICU length of stay (LOS). There was a difference in morphine equivalents per hour: non-IVL = 1.25 vs IVL = 1.72 (P = .004) and LOS non-IVL = 10.2+/-7.6 vs IVL = 7.82+/-4.94. By analyzing IVL pts in a crossover comparison before and after IVL, there was reduction in opiates: 3.01 vs 1.72 (P < .001) and PS: 7.0 vs 4.9 (P < .001). Stanford Pain Score system reduction in the IVL = 48.3 ± 23.9%, but less effective in narcotic dependency (27 ± 22.9%, P = .035); IVL pts had hospital cost reduction: $82,927 vs $118,202 (P < .01). Discussion: In a crossover analysis, IVL is effective for reduction of PS and opiate use and reduces hospital LOS and costs. Patient age may confound interpretation of results. Our data support IVL use in multimodal pain regimens. Future prospective study is warranted.
2. Co-pyrolysis of biomass and waste tires under high-pressure two-stage fixed bed reactor
Fengchao Wang, Ningbo Gao, Aneta Magdziarz, Cui Quan Bioresour Technol. 2022 Jan;344(Pt B):126306. doi: 10.1016/j.biortech.2021.126306. Epub 2021 Nov 13.
The distribution of biomass pyrolysis products under high pressure have rarely been reported. In this study, the effect of pressure on the product distribution of pine sawdust (PS) pyrolysis was studied. The synergistic effect of the side wall rubber (SWR) and PS was confirmed under pressurized conditions. Calcined bottom ash (CBA) and SWR char (SWRC) were used to enhance the quality of the pressurized co-pyrolysis products. The PS and SWR pyrolysis chars obtained under high pressure conditions exhibited serious melting and cross-linking problem. The CO2 content decreased to 19.96 vol% in co-pyrolysis gas with the CBA/SWRC7/3 catalyst. The water content decreased by 85.71% after the SWRC catalyst in the pressurized co-pyrolysis process. Compared with the concentration of benzene in PS and SWR oil, the concentration of benzene in SWR/PS7/3 oil without catalysts increased by 9.57 times and 0.25 times, respectively.
3. Correlation-based transceiver in-phase/ quadrature skew in-field calibration in dual-polarization coherent optical transmission system
Xiaowu Wang, Fan Li, Mingzhu Yin, Zhibin Luo, Simiao Qin, Wei Wang, Yi Cai, Zhaohui Li Opt Express. 2022 Jun 20;30(13):22712-22729. doi: 10.1364/OE.459865.
In this paper, we propose a novel transceiver in-phase/quadrature (I/Q) skew in-field calibration scheme with correlation-based method for the dual-polarization coherent optical system. Simultaneous dual-polarization calibration of transceiver I/Q skews after fiber transmission is experimentally performed. Rx/Tx correlation-based skew estimations (CBSEs) are proposed to accurately estimate the transceiver I/Q skews with dual-polarization OFDM signal. By simulation, the robustness of the Rx/Tx CBSEs is investigated against various transceiver I/Q imbalances and channel impairments including carrier frequency offset (CFO), phase noise (PN), and chromatic dispersion (CD). The simultaneous measurement of large transceiver skews is studied within a range of ±128 ps. The bit error rate (BER) improvement brought by the CBSEs is studied in 80 km single-mode fiber (SMF) transmissions under various Rx/Tx skews. In the experiments, the Rx/Tx skew is measured in the range of 1 to 128 ps w/ and w/o the presence of 5 ps Tx/Rx skew. Simultaneous dual-polarization measurements are performed with the X/Y polarization Tx/Rx skews set to 2.5 ps, 5 ps, 7.5 ps and 10 ps, respectively. The measurement errors are within ±0.2 ps. The 80 km SMF dual-polarization transmission after in-field calibration for inter-data center interconnection (inter-DCI) is implemented, with a data rate of 400 Gb/s for both 16QAM and 32QAM modulation formats.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
