Pyloricidin A1
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02080 |
| CAS | |
| Molecular Weight | 667.79 |
| Molecular Formula | C32H53N5O10 |
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Description
Pyloricidin A1 is an antibiotic against Helicobacter pylori produced by Bacillus sp. HC-70. It has strong anti-Helicobacter pylori activity, with a MIC of 0.0625 pig/mL. It has no activity against other bacteria and yeast.
Specification
| IUPAC Name | 3-[[5-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-2,3,4,6-tetrahydroxyhexanoyl]amino]-3-phenylpropanoic acid |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(C(C(C(=O)NC(CC(=O)O)C1=CC=CC=C1)O)O)O)NC(=O)C(C(C)C)N |
| InChI | InChI=1S/C32H53N5O10/c1-7-18(6)25(37-30(45)24(33)17(4)5)31(46)35-21(13-16(2)3)29(44)36-22(15-38)26(41)27(42)28(43)32(47)34-20(14-23(39)40)19-11-9-8-10-12-19/h8-12,16-18,20-22,24-28,38,41-43H,7,13-15,33H2,1-6H3,(H,34,47)(H,35,46)(H,36,44)(H,37,45)(H,39,40)/t18-,20?,21-,22?,24-,25-,26?,27?,28?/m0/s1 |
| InChI Key | GCTBIAPBXCZZKV-QPRGNFKZSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-negative bacteria |
| Boiling Point | 1072.5±65.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity
M Nakao, K Miyagaw, Y Nakano, T Sakane, M Tada, O Nishimura, M Fujino J Antibiot (Tokyo). 2001 Nov;54(11):926-33. doi: 10.7164/antibiotics.54.926.
Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
