Pyralomicin 2a
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| Category | Antibiotics |
| Catalog number | BBF-02090 |
| CAS | 139636-00-3 |
| Molecular Weight | 460.26 |
| Molecular Formula | C19H19Cl2NO8 |
Online Inquiry
Description
Pyralomicin 2a is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity.
Specification
| IUPAC Name | 2,6-dichloro-1-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-5-hydroxy-8-methylchromeno[2,3-b]pyrrol-4-one |
| Canonical SMILES | CC1=CC(=C(C2=C1OC3=C(C2=O)C=C(N3C4C(C(C(C(O4)CO)OC)O)O)Cl)O)Cl |
| InChI | InChI=1S/C19H19Cl2NO8/c1-6-3-8(20)13(25)11-12(24)7-4-10(21)22(18(7)30-16(6)11)19-15(27)14(26)17(28-2)9(5-23)29-19/h3-4,9,14-15,17,19,23,25-27H,5H2,1-2H3/t9-,14-,15-,17-,19-/m1/s1 |
| InChI Key | ZXYNPGZWOMFXHV-JUTSKPLTSA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | bacteria |
| Boiling Point | 745.2±60.0°C at 760 mmHg |
| Melting Point | 295-297°C (dec.) |
| Density | 1.8±0.1 g/cm3 |
Reference Reading
1. Pyralomicins, novel antibiotics from Microtetraspora spiralis. II. Structure determination
N Kawamura, R Sawa, Y Takahashi, K Isshiki, T Sawa, H Naganawa, T Takeuchi J Antibiot (Tokyo). 1996 Jul;49(7):651-6. doi: 10.7164/antibiotics.49.651.
Novel antibiotics, pyralomicins 1a approximately 1d, 2a approximately 2c were isolated from the culture broth of Microtetraspora spiralis MI178-34F18. The structures of pyralomicins were determined by various NMR spectral analyses including 1H-15N HMBC and 13C¿1H¿ NOE difference experiments.
2. Pyralomicins, novel antibiotics from Microtetraspora spiralis. IV. Absolute configuration
N Kawamura, H Nakamura, R Sawa, Y Takahashi, T Sawa, H Naganawa, T Takeuchi J Antibiot (Tokyo). 1997 Feb;50(2):147-9. doi: 10.7164/antibiotics.50.147.
The absolute configurations of pyralomicin la and pyralomicin 2a were determined by X-ray crystallographic analyses of crystalline 7'-O-p-bromobenzoylpyralomicin 1a and 2'-O-p-bromobenzoylpyralomicin 2a derived from pyralomicin 1a and pyralomicin 2a using anomalous scattering of the bromine atom. The absolute configurations of pyralomicins 1b approximately 1d and 2b approximately 2e were suggested to be the same as pyralomicin 1a and pyralomicin 2a, respectively, by comparing the circular dichroism spectra.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
