Pyrisulfoxin B
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02100 |
| CAS | |
| Molecular Weight | 273.31 |
| Molecular Formula | C13H11N3O2S |
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Description
Pyrisulfoxin B is an antibiotic produced by Streptomyces callfornicus BS-75.
Specification
| IUPAC Name | 4-methoxy-3-methylsulfinyl-6-pyridin-2-ylpyridine-2-carbonitrile |
| Canonical SMILES | COC1=CC(=NC(=C1S(=O)C)C#N)C2=CC=CC=N2 |
| InChI | InChI=1S/C13H11N3O2S/c1-18-12-7-10(9-5-3-4-6-15-9)16-11(8-14)13(12)19(2)17/h3-7H,1-2H3 |
| InChI Key | CEEFKOCHZZDNPV-UHFFFAOYSA-N |
Properties
| Appearance | Powder |
| Boiling Point | 516.2±50.0°C at 760 mmHg |
| Melting Point | 163-165°C |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation
Jin-Hyung Lee, Eonmi Kim, Hyukjae Choi, Jintae Lee Mar Drugs. 2017 Dec 12;15(12):387. doi: 10.3390/md15120387.
Biofilm formation plays a critical role in antimicrobial resistance in Staphylococcus aureus. Here, we investigated the potential of crude extracts of 79 Micronesian marine microorganisms to inhibit S. aureus biofilm formation. An extract of Streptomyces sp. MC025 inhibited S. aureus biofilm formation. Bioactivity-guided isolation led to the isolation of a series of 2,2'-bipyridines: collismycin B (1), collismycin C (2), SF2738 D (3), SF2738 F (4), pyrisulfoxin A (5), and pyrisulfoxin B (6). Among these bipyridines, collismycin C (2) was found to be the most effective inhibitor of biofilm formation by methicillin-sensitive S. aureus and methicillin-resistant S. aureus (MRSA), and this compound inhibited MRSA biofilm formation by more than 90% at a concentration of 50 μg/mL. The antibiofilm activity of collismycin C was speculated to be related to iron acquisition and the presence and position of the hydroxyl group of 2,2'-bipyridines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
