Pyrrolomycin A
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| Category | Antibiotics |
| Catalog number | BBF-02101 |
| CAS | 79763-01-2 |
| Molecular Weight | 180.97 |
| Molecular Formula | C4H2Cl2N2O2 |
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Description
Pyrrolomycin A is a pyrrole antibiotic produced by Adinosporangium vitaminophilum SF-2080. It has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
Specification
| Synonyms | 2,3-Dichloro-4-nitropyrrole |
| IUPAC Name | 2,3-dichloro-4-nitro-1H-pyrrole |
| Canonical SMILES | C1=C(C(=C(N1)Cl)Cl)[N+](=O)[O-] |
| InChI | InChI=1S/C4H2Cl2N2O2/c5-3-2(8(9)10)1-7-4(3)6/h1,7H |
| InChI Key | CDHAYBUDIPNGGJ-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; fungi |
| Boiling Point | 325.5°C at 760 mmHg |
| Density | 1.748 g/cm3 |
Reference Reading
1. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins
Stella Cascioferro, Maria Valeria Raimondi, Maria Grazia Cusimano, Demetrio Raffa, Benedetta Maggio, Giuseppe Daidone, Domenico Schillaci Molecules. 2015 Dec 4;20(12):21658-71. doi: 10.3390/molecules201219797.
The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
