Pyrrolomycin E
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| Category | Antibiotics |
| Catalog number | BBF-02102 |
| CAS | 87376-16-7 |
| Molecular Weight | 307.52 |
| Molecular Formula | C10H5Cl3N2O3 |
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Description
Pyrrolomycin E is a pyrrole antibiotic produced by Adinosporangium vitaminophilum SF-2080. It has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
Specification
| IUPAC Name | 2,4-dichloro-6-(5-chloro-3-nitro-1H-pyrrol-1-ium-2-yl)phenol |
| Canonical SMILES | C1=C(C=C(C(=C1C2=C(C=C([NH2+]2)Cl)[N+](=O)[O-])O)Cl)Cl |
| InChI | InChI=1S/C10H5Cl3N2O3/c11-4-1-5(10(16)6(12)2-4)9-7(15(17)18)3-8(13)14-9/h1-3,14,16H/p+1 |
| InChI Key | SGEOBHBCFXDBHD-UHFFFAOYSA-O |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; fungi |
| Boiling Point | 456.3°C at 760 mmHg |
| Density | 1.716 g/cm3 |
Reference Reading
1. Pyrrolomycins C, D and E, new members of pyrrolomycins
N Ezaki, M Koyama, T Shomura, T Tsuruoka, S Inouye J Antibiot (Tokyo). 1983 Oct;36(10):1263-7. doi: 10.7164/antibiotics.36.1263.
Pyrrolomycins C, D and E, new members of pyrrolomycins produced by Actinosporangium vitaminophilum SF-2080, have been isolated by chromatography on a basic alumina column. Three antibiotics have chlorinated pyrrole nuclei linked directly or via carbonyl function to the dichlorophenol moiety. Pyrrolomycins C and E are active against Gram-positive bacteria, while the spectrum of pyrrolomycin D is broad including Gram-positive, Gram-negative bacteria and fungi.
2. Structural studies on pyrrolomycins C, D and E
M Koyama, N Ezaki, T Tsuruoka, S Inouye J Antibiot (Tokyo). 1983 Nov;36(11):1483-9. doi: 10.7164/antibiotics.36.1483.
Pyrrolomycins C, D and E are new members of the pyrrolomycin group of antibiotics produced by an Actinosporangium sp. The structures of pyrrolomycins C and D were determined to be 2,3-dichloro-5-(3',5'-dichloro-2'-hydroxybenzoyl)pyrrole and 2,3,4-trichloro-5-(3',5'-dichloro-2'-hydroxybenzoyl)pyrrole, respectively, by means of spectroscopic and synthetic approaches while that of pyrrolomycin E was shown to be 5-chloro-2-(3',5'-dichloro-2'-hydroxyphenyl)-3-nitropyrrole by spectroscopic data.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
