Quinaldopeptin
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Category | Antibiotics |
Catalog number | BBF-04192 |
CAS | 130743-07-6 |
Molecular Weight | 1243.37 |
Molecular Formula | C62H78N14O14 |
Purity | >95% by HPLC |
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Description
It is a symmetrical, cyclic decapeptide from an amycolatopsis sp. This is a bis-intercalator of DNA. It exhibits strong in vitro antimicrobial and cytotoxic activity. It significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. It is related to the luzopeptins and sandramycin.
Specification
Synonyms | Antibiotic BMY 28662; Antibiotic BU 3845T; BMY 28662; BU 3845T |
Storage | Store at -20°C |
IUPAC Name | 3-hydroxy-N-[(3R,4S,7S,20S,27R,28S,31S,44R)-27-[(3-hydroxyquinoline-2-carbonyl)amino]-4,15,28,39-tetramethyl-2,6,13,16,19,26,30,37,40,43-decaoxo-1,5,12,15,18,25,29,36,39,42-decazapentacyclo[42.4.0.07,12.020,25.031,36]octatetracontan-3-yl]quinoline-2-carboxamide |
Canonical SMILES | CC1C(C(=O)N2CCCCC2C(=O)NCC(=O)N(CC(=O)N3CCCCC3C(=O)NC(C(C(=O)N4CCCCC4C(=O)NCC(=O)N(CC(=O)N5CCCCC5C(=O)N1)C)NC(=O)C6=NC7=CC=CC=C7C=C6O)C)C)NC(=O)C8=NC9=CC=CC=C9C=C8O |
InChI | InChI=1S/C62H78N14O14/c1-35-51(69-59(87)53-45(77)29-37-17-5-7-19-39(37)67-53)61(89)75-27-15-11-21-41(75)55(83)63-31-47(79)72(4)34-50(82)74-26-14-10-24-44(74)58(86)66-36(2)52(70-60(88)54-46(78)30-38-18-6-8-20-40(38)68-54)62(90)76-28-16-12-22-42(76)56(84)64-32-48(80)71(3)33-49(81)73-25-13-9-23-43(73)57(85)65-35/h5-8,17-20,29-30,35-36,41-44,51-52,77-78H,9-16,21-28,31-34H2,1-4H3,(H,63,83)(H,64,84)(H,65,85)(H,66,86)(H,69,87)(H,70,88)/t35-,36-,41-,42+,43-,44-,51+,52+/m0/s1 |
InChI Key | KIPSHYPQCJYONU-WZMSAHAESA-N |
Source | Amycolatopsis sp. |
Properties
Appearance | Yellow Powder |
Antibiotic Activity Spectrum | Gram-positive bacteria; Parasites |
Melting Point | 300°C |
Density | 1.45 g/cm3 |
Solubility | Soluble in DMF, DMSO, Chloroform, Acetone |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2