RES-1214-1
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| Category | Bioactive by-products |
| Catalog number | BBF-03365 |
| CAS | |
| Molecular Weight | 348.3 |
| Molecular Formula | C17H16O8 |
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Description
RES-1214-1 is an endothelin type A receptor antagonist produced by Pestalotiopsis sp. RE-1214. It selectively inhibits the ET-1 binding to endothelin type A receptor with IC50 value of 1.5 µmol/L.
Specification
| IUPAC Name | 2-hydroxy-6-(2-hydroxy-4-methoxy-6-methoxycarbonylphenoxy)-4-methylbenzoic acid |
| Canonical SMILES | CC1=CC(=C(C(=C1)OC2=C(C=C(C=C2O)OC)C(=O)OC)C(=O)O)O |
| InChI | InChI=1S/C17H16O8/c1-8-4-11(18)14(16(20)21)13(5-8)25-15-10(17(22)24-3)6-9(23-2)7-12(15)19/h4-7,18-19H,1-3H3,(H,20,21) |
| InChI Key | SOXXAFVUSIMAGB-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
Reference Reading
1. RES-1214-1 and -2, novel non-peptidic endothelin type A receptor antagonists produced by Pestalotiopsis sp
T Ogawa, K Ando, Y Aotani, K Shinoda, T Tanaka, E Tsukuda, M Yoshida, Y Matsuda J Antibiot (Tokyo). 1995 Dec;48(12):1401-6. doi: 10.7164/antibiotics.48.1401.
RES-1214-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the cultured broth of a fungus, Pestalotiopsis sp. RE-1214. RES-1214-1 and -2 selectivity inhibited the ET-1 binding to endothelin type A receptor (ETA receptor) with IC50 values of 1.5 microM and 10 microM, respectively. RES-1214-1 and -2 inhibited the increase in intracellular Ca2+ concentration elicited by 1 nM ET-1 in A10 cells. Taxonomy of producing strains, fermentation, isolation, structural determination, and biochemical properties of RES-1214-1 and-2 are described.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
