Roquefortine C
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Category | Mycotoxins |
Catalog number | BBF-04314 |
CAS | 58735-64-1 |
Molecular Weight | 389.45 |
Molecular Formula | C22H23N5O2 |
Purity | >99% by HPLC |
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Capabilities & Facilities
Fermentation Lab
4 R&D and scale-up labs
2 Preparative purification labs
Fermentation Plant
Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
A potent tremorgenic mycotoxin originally isolated from penicillium roqueforti. It is a penicillium commercially used to ripen blue-veined cheese.
- Specification
- Properties
- Toxicity
- Reference Reading
- Spectrum
- Price Product List
Synonyms | Roquefortine; NSC 292134; (3E,5aS,10bR,11aS)-10b-(1,1-Dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione; (-)-Roquefortine C; Roquefortin |
Storage | Store at -20°C |
IUPAC Name | (1S,4E,7S,9R)-4-(1H-imidazol-5-ylmethylidene)-9-(2-methylbut-3-en-2-yl)-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione |
Canonical SMILES | CC(C)(C=C)C12CC3C(=O)NC(=CC4=CN=CN4)C(=O)N3C1NC5=CC=CC=C25 |
InChI | InChI=1S/C22H23N5O2/c1-4-21(2,3)22-10-17-18(28)25-16(9-13-11-23-12-24-13)19(29)27(17)20(22)26-15-8-6-5-7-14(15)22/h4-9,11-12,17,20,26H,1,10H2,2-3H3,(H,23,24)(H,25,28)/b16-9+/t17-,20-,22+/m0/s1 |
InChI Key | SPWSUFUPTSJWNG-JJUKSXGLSA-N |
Source | Roquefortine C is a tremorgenic mycotoxin produced primarily by Penicillium roquefortii, but also by other Penicillium species. |
Appearance | White Lyophilisate |
Boiling Point | 768.3°C at 760 mmHg |
Melting Point | 202-205°C |
Density | 1.37 g/cm3 |
Solubility | Soluble in Ethanol, Methanol, DMF, DMSO; Poorly soluble in Water |
Carcinogenicity | No indication of carcinogenicity to humans (not listed by IARC). |
Mechanism Of Toxicity | Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. Roquefortine C also interacts with different forms of the cytochromes. |
Toxicity | LD50: 15-20 mg/kg (Intraperitoneal, Mouse). |
Predicted LC-MS/MS Spectrum - 10V, Positive

Experimental Conditions
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
