S-15183b
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03396 |
| CAS | |
| Molecular Weight | 444.6 |
| Molecular Formula | C27H40O5 |
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Description
S-15183b is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 µmol/L.
Specification
| Synonyms | S-15183 b |
| IUPAC Name | (3-heptyl-7-methyl-6,8-dioxoisochromen-7-yl) decanoate |
| Canonical SMILES | CCCCCCCCCC(=O)OC1(C(=O)C=C2C=C(OC=C2C1=O)CCCCCCC)C |
| InChI | InChI=1S/C27H40O5/c1-4-6-8-10-11-13-15-17-25(29)32-27(3)24(28)19-21-18-22(16-14-12-9-7-5-2)31-20-23(21)26(27)30/h18-20H,4-17H2,1-3H3 |
| InChI Key | ZCUXUVQISKVJGB-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Oily Matter |
Reference Reading
1. S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus
K Kono, M Tanaka, Y Ono, T Hosoya, T Ogita, T Kohama J Antibiot (Tokyo). 2001 May;54(5):415-20. doi: 10.7164/antibiotics.54.415.
In the course of our screening for inhibitors of sphingosine kinase, we found two active compounds in a culture broth of a fungus, Zopfiella inermis SANK 15183. The structures of the compounds, named S-15183a and b, were elucidated by a combination of spectroscopic analyses to be new azaphilone-type metabolites. S-15183a and b inhibited sphingosine kinase from rat liver with IC50 values of 2.5 and 1.6 microM, respectively. S-15183a also inhibited endogenous SPH kinase activity in intact platelets.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
