S-19159

S-19159

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Category Bioactive by-products
Catalog number BBF-03397
CAS
Molecular Weight 484.7
Molecular Formula C30H44O5

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Description

S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans.

Specification

Synonyms S 19159; S19159
IUPAC Name (1R,3S,6S,7S,8R,12R,15R,16R,18R)-6,18-dihydroxy-7,16-dimethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]-4-oxopentacyclo[9.7.0.01,3.03,8.012,16]octadec-10-ene-7-carboxylic acid
Canonical SMILES CC(C)C(=C)CCC(C)C1CCC2C1(CC(C34C2=CCC5C3(C4)C(=O)CC(C5(C)C(=O)O)O)O)C
InChI InChI=1S/C30H44O5/c1-16(2)17(3)7-8-18(4)19-9-10-20-21-11-12-22-28(6,26(34)35)23(31)13-24(32)30(22)15-29(21,30)25(33)14-27(19,20)5/h11,16,18-20,22-23,25,31,33H,3,7-10,12-15H2,1-2,4-6H3,(H,34,35)/t18-,19-,20+,22+,23+,25-,27-,28+,29+,30-/m1/s1
InChI Key YHBXMVZOQPOYGU-FDOZPVTESA-N

Properties

Melting Point >196°C (dec.)

Reference Reading

1. S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. I. Producing strain, fermentation, isolation and biological activity
T Sato, T Hanada, M Arioka, K Ando, J Sugiyama, M Uramoto, M Yamasaki, K Kitamoto J Antibiot (Tokyo). 1998 Oct;51(10):897-901. doi: 10.7164/antibiotics.51.897.
A modulator of neurite outgrowth, designated S19159, was isolated from the fermentation broth of fungal strain 19159. This fungus was identified as the loculoascomycete, Preussia aemulans (Rehm) von Arx. In the presence of S19159, the number of neurites extending from the cell bodies of cerebral cortical neurons was markedly reduced. The effect of S19159 was observed specifically in neurons from the central nervous system. The compound exhibited similar activities on cultured cortical, hippocampal and cerebeller neurons but was without detectable effect on dorsal root ganglion neurons and PC12 cells.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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