S-19159
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| Category | Bioactive by-products |
| Catalog number | BBF-03397 |
| CAS | |
| Molecular Weight | 484.7 |
| Molecular Formula | C30H44O5 |
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Description
S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans.
Specification
| Synonyms | S 19159; S19159 |
| IUPAC Name | (1R,3S,6S,7S,8R,12R,15R,16R,18R)-6,18-dihydroxy-7,16-dimethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]-4-oxopentacyclo[9.7.0.01,3.03,8.012,16]octadec-10-ene-7-carboxylic acid |
| Canonical SMILES | CC(C)C(=C)CCC(C)C1CCC2C1(CC(C34C2=CCC5C3(C4)C(=O)CC(C5(C)C(=O)O)O)O)C |
| InChI | InChI=1S/C30H44O5/c1-16(2)17(3)7-8-18(4)19-9-10-20-21-11-12-22-28(6,26(34)35)23(31)13-24(32)30(22)15-29(21,30)25(33)14-27(19,20)5/h11,16,18-20,22-23,25,31,33H,3,7-10,12-15H2,1-2,4-6H3,(H,34,35)/t18-,19-,20+,22+,23+,25-,27-,28+,29+,30-/m1/s1 |
| InChI Key | YHBXMVZOQPOYGU-FDOZPVTESA-N |
Properties
| Melting Point | >196°C (dec.) |
Reference Reading
1. S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. I. Producing strain, fermentation, isolation and biological activity
T Sato, T Hanada, M Arioka, K Ando, J Sugiyama, M Uramoto, M Yamasaki, K Kitamoto J Antibiot (Tokyo). 1998 Oct;51(10):897-901. doi: 10.7164/antibiotics.51.897.
A modulator of neurite outgrowth, designated S19159, was isolated from the fermentation broth of fungal strain 19159. This fungus was identified as the loculoascomycete, Preussia aemulans (Rehm) von Arx. In the presence of S19159, the number of neurites extending from the cell bodies of cerebral cortical neurons was markedly reduced. The effect of S19159 was observed specifically in neurons from the central nervous system. The compound exhibited similar activities on cultured cortical, hippocampal and cerebeller neurons but was without detectable effect on dorsal root ganglion neurons and PC12 cells.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
