Salfredin C3
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02859 |
| CAS | 139542-58-8 |
| Molecular Weight | 349.29 |
| Molecular Formula | C16H15NO8 |
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Description
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.
Specification
| IUPAC Name | (2R)-2-[(2S)-6-(1-carboxyethyl)-4-hydroxy-5,7-dioxo-2,3-dihydrofuro[3,2-f]isoindol-2-yl]propanoic acid |
| Canonical SMILES | CC(C1CC2=C(O1)C=C3C(=C2O)C(=O)N(C3=O)C(C)C(=O)O)C(=O)O |
| InChI | InChI=1S/C16H15NO8/c1-5(15(21)22)9-3-7-10(25-9)4-8-11(12(7)18)14(20)17(13(8)19)6(2)16(23)24/h4-6,9,18H,3H2,1-2H3,(H,21,22)(H,23,24)/t5-,6?,9+/m1/s1 |
| InChI Key | VQOAQUIDELNUAB-NCUFMZKJSA-N |
Properties
| Appearance | Pale Yellow Oily Matter |
| Solubility | Soluble in Methanol, Ethyl Acetate, Ether, Ethanol |
Reference Reading
1. A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity
Xixi Liu, Haji Akber Aisa, Xuelei Xin Nat Prod Res. 2019 Feb;33(4):472-476. doi: 10.1080/14786419.2017.1396594. Epub 2017 Oct 31.
A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38 ± 0.14 μM in vitro.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
