Sch 42137
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| Category | Antibiotics |
| Catalog number | BBF-02424 |
| CAS | 142383-44-6 |
| Molecular Weight | 549.5 |
| Molecular Formula | C29H27NO10 |
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Description
Sch 42137 is an antifungal antibiotic isolated from Actinoplanes sp. It exhibited MIC values less than 0.125 μg/mL against yeasts and dermatophytes.
Specification
| Synonyms | Antibiotic Sch 42137; Sch-42137 |
| IUPAC Name | 24-ethyl-3,7,10,28-tetrahydroxy-14-methoxy-25-methyl-12,18,20-trioxa-25-azaheptacyclo[15.11.1.02,15.04,13.06,11.021,29.022,27]nonacosa-1(28),2(15),3,6(11),13,21(29),22(27),23-octaene-5,26-dione |
| Canonical SMILES | CCC1=CC2=C(C(=C3C4=C2OCOC4CC5=C3C(=C6C(=C5OC)OC7=C(C6=O)C(CCC7O)O)O)O)C(=O)N1C |
| InChI | InChI=1S/C29H27NO10/c1-4-10-7-11-17(29(36)30(10)2)23(34)20-16-12(8-15-19(20)25(11)39-9-38-15)26(37-3)28-21(22(16)33)24(35)18-13(31)5-6-14(32)27(18)40-28/h7,13-15,31-34H,4-6,8-9H2,1-3H3 |
| InChI Key | SLGIZIDCEVQLHR-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | fungi; yeast |
| Boiling Point | 946°C at 760 mmHg |
| Density | 1.66 g/cm3 |
Reference Reading
1. Sch 42137, a novel antifungal antibiotic from an Actinoplanes sp. Fermentation, isolation, structure and biological properties
R Cooper, I Truumees, I Gunnarsson, D Loebenberg, A Horan, J Marquez, M Patel, V Gullo, M Puar, P Das, et al. J Antibiot (Tokyo). 1992 Apr;45(4):444-53. doi: 10.7164/antibiotics.45.444.
A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values less than 0.125 micrograms/ml against yeasts and dermatophytes. Details are presented herein.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
