Sch 42137

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Category Antibiotics
Catalog number BBF-02424
CAS 142383-44-6
Molecular Weight 549.5
Molecular Formula C29H27NO10

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Description

Sch 42137 is an antifungal antibiotic isolated from Actinoplanes sp. It exhibited MIC values less than 0.125 μg/mL against yeasts and dermatophytes.

Specification

Synonyms Antibiotic Sch 42137; Sch-42137
IUPAC Name 24-ethyl-3,7,10,28-tetrahydroxy-14-methoxy-25-methyl-12,18,20-trioxa-25-azaheptacyclo[15.11.1.02,15.04,13.06,11.021,29.022,27]nonacosa-1(28),2(15),3,6(11),13,21(29),22(27),23-octaene-5,26-dione
Canonical SMILES CCC1=CC2=C(C(=C3C4=C2OCOC4CC5=C3C(=C6C(=C5OC)OC7=C(C6=O)C(CCC7O)O)O)O)C(=O)N1C
InChI InChI=1S/C29H27NO10/c1-4-10-7-11-17(29(36)30(10)2)23(34)20-16-12(8-15-19(20)25(11)39-9-38-15)26(37-3)28-21(22(16)33)24(35)18-13(31)5-6-14(32)27(18)40-28/h7,13-15,31-34H,4-6,8-9H2,1-3H3
InChI Key SLGIZIDCEVQLHR-UHFFFAOYSA-N

Properties

Antibiotic Activity Spectrum fungi; yeast
Boiling Point 946°C at 760 mmHg
Density 1.66 g/cm3

Reference Reading

1. Sch 42137, a novel antifungal antibiotic from an Actinoplanes sp. Fermentation, isolation, structure and biological properties
R Cooper, I Truumees, I Gunnarsson, D Loebenberg, A Horan, J Marquez, M Patel, V Gullo, M Puar, P Das, et al. J Antibiot (Tokyo). 1992 Apr;45(4):444-53. doi: 10.7164/antibiotics.45.444.
A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values less than 0.125 micrograms/ml against yeasts and dermatophytes. Details are presented herein.

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