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Sch 466457

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Category Bioactive by-products
Catalog number BBF-02437
CAS
Molecular Weight 1702.08
Molecular Formula C80H140N20O20

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Sch 466457 is a peptide active against Candida, dermatophytes and Aspergillus with MIC of 8.9, 20 and 16 microg/mL.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms Sch-466457
Appearance White Amorphous Powder
Melting Point 204°C
1. Novel fungal metabolites as cell wall active antifungals: fermentation, isolation, physico-chemical properties, structure and biological activity
V R Hegde, J Silver, M Patel, V P Gullo, R Yarborough, E Huang, P R Das, M S Puar, B J DiDomenico, D Loebenberg J Antibiot (Tokyo). 2001 Jan;54(1):74-83. doi: 10.7164/antibiotics.54.74.
Two novel antifungal compounds, 1 (SCH 466457), and 2 (SCH 466456), active in a "cell wall" assay, were isolated from the fermentation broth of an unidentified fungus. The active compounds were separated from the broth filtrate by adsorption on a macroreticular resin and were purified on reverse phase HPLC. Detailed mass spectrometric and NMR experiments and degradative studies helped in elucidating the structures of these compounds. The compounds were identified to be peptides containing amino acids such as alanine, aminoisobutyric acid, proline, leucine, valine, glycine and a previously identified beta-keto acid, 2-methyl 3-oxotetradecanoic acid. (5) Both compounds were active against Candida, dermatophytes and Aspergillus (Geometric Mean MIC's, 8.9, 20 and 16 microg/ml, and 64, 128 and 23 microg/ml, respectively for 1 and 2).

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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