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SF 2446A1

Name: SF 2446A1
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Antibiotics
Catalog number	BBF-02454
CAS
Molecular Weight	697.6
Molecular Formula	C34H35NO15

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

SF 2446A1 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria.

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Synonyms

Antibiotic SF 2446A1; SF2446A1

Appearance	Dark Red Crystal
Antibiotic Activity Spectrum	Gram-positive bacteria; mycoplasma
Melting Point	203-205°C

1. SF2446, new benzo[a]naphthacene quinone antibiotics. II. The structural elucidation

S Gomi, T Sasaki, J Itoh, M Sezaki J Antibiot (Tokyo). 1988 Apr;41(4):425-32. doi: 10.7164/antibiotics.41.425.

Structures of new antibiotics SF2446A1, A2, A3, B1, B2 and B3 have been deduced by means of spectral analyses and chemical studies. The structure of SF2446A1 which is a main product of fermentation and has the strongest antimicrobial activity, has been proposed to be 11-(2,4-di-O-methyl-beta-L-rhamnopyranosyl)amino-5,6,6a,14a-tetrah ydro- 1,6,8,14a-tetrahydroxy-6a-methoxy-2-methoxycarbonyl-3-methyl- benzo[a]naphthacene-7,9,12,14-tetra-one. All of antibiotics have a novel benzo[a]naphthacene quinone skeleton and SF2446A1, A2, B1 and B2 have an N-glycosidic linkage with 2,4-di-O-methyl-L-rhamnose.

2. SF2446, new benzo[a]naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics

U Takeda, T Okada, M Takagi, S Gomi, J Itoh, M Sezaki, M Ito, S Miyadoh, T Shomura J Antibiot (Tokyo). 1988 Apr;41(4):417-24. doi: 10.7164/antibiotics.41.417.

New antibiotics SF2446A1, A2, A3, B1 and B2 have been isolated from the culture of Streptomyces sp. SF2446 and antibiotic SF2446B3 has been obtained by methanolysis of SF2446B1 or B2. SF2446A1, A2 and B1 showed strong inhibitory activities against mycoplasmas and Gram-positive bacteria. Empirical molecular formulae of antibiotics SF2446-A1, A2, A3, B1, B2 and B3 were determined to be C34H35NO15, C26H21NO11, C34H35NO14, C34H35NO14 and C26H21NO10, respectively.

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