SF 2487

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Category Antibiotics
Catalog number BBF-02460
CAS
Molecular Weight 782.9
Molecular Formula C42H63NaO12

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Description

SF 2487 is a polyether antibiotic produced by Actinomadura sp. SF2487. It has moderate activity against gram-positive bacteria including staphylococcus and enterococcus with MIC of 0.10-0.39 μg/mL. It also effective against Influenza A virus.

Specification

Synonyms SF-2487; SF2487; SF 2487 sodium salt; Antibiotic SF 2487 sodium salt; LS-70212

Properties

Appearance Crystal
Antibiotic Activity Spectrum Gram-positive bacteria; viruses
Melting Point 250-252°C (dec.)

Reference Reading

1. SF2487, a new polyether antibiotic produced by Actinomadura
M Hatsu, T Sasaki, S Miyadoh, H Watabe, Y Takeuchi, Y Kodama, Y Orikasa, K Kajii, T Shomura, H Yamamoto, et al. J Antibiot (Tokyo). 1990 Mar;43(3):259-66. doi: 10.7164/antibiotics.43.259.
A new antibiotic SF2487 has been isolated from the culture broth of Actinomadura sp. SF2487. The structure of antibiotic SF2487 was determined by spectroscopic analyses of the sodium salt and X-ray diffraction analysis of the silver salt. The antibiotic represents a new member of polyether group antibiotics known as the acyltetronic acid type 4. The antibiotic is weakly active against Gram-positive bacteria and exhibits antiviral activity against influenza virus in vitro.

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