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SF2457

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Category Antibiotics
Catalog number BBF-02459
CAS 115748-04-4
Molecular Weight 590.6
Molecular Formula C27H38N6O9

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

SF2457 is an antibiotic related to amicetin, which is isolated from the fermentation broth of Nocardia brasiliensis SF2457. It exhibits inhibitory activity against Gram-positive and Gram-negative bacteria.

  • Specification
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Synonyms SF-2457; SF 2457
IUPAC Name 4-[[(2R)-2-aminopropanoyl]amino]-N-[1-[(2R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-(methylamino)oxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]-2-oxopyrimidin-4-yl]benzamide
Canonical SMILES CC1C(C(C(C(O1)OC2C(OC(CC2O)N3C=CC(=NC3=O)NC(=O)C4=CC=C(C=C4)NC(=O)C(C)N)C)O)O)NC
InChI InChI=1S/C27H38N6O9/c1-12(28)24(37)30-16-7-5-15(6-8-16)25(38)31-18-9-10-33(27(39)32-18)19-11-17(34)23(14(3)40-19)42-26-22(36)21(35)20(29-4)13(2)41-26/h5-10,12-14,17,19-23,26,29,34-36H,11,28H2,1-4H3,(H,30,37)(H,31,32,38,39)/t12-,13-,14-,17-,19-,20-,21+,22-,23-,26-/m1/s1
InChI Key MRCNWCHLQHYMMZ-AOHSPZNCSA-N
Appearance Solid Powder
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria
Melting Point 172-174°C (dec.)
1. SF2457, a new antibiotic related to amicetin
J Itoh, S Miyadoh J Antibiot (Tokyo). 1992 Jun;45(6):846-53. doi: 10.7164/antibiotics.45.846.
A novel nucleoside antibiotic, SF2457, was isolated from the fermentation broth of Nocardia brasiliensis SF2457. The structure of SF2457 was determined by degradation studies using alkaline hydrolysis and methanolysis. SF2457 is closely related to the amicetin group antibiotics. The antibiotic exhibited inhibitory activity against Gram-positive and Gram-negative bacteria.

Bio Calculators

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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