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SO-75R1

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-02483
CAS 143458-82-6
Molecular Weight 558.66
Molecular Formula C29H34O11

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

SO-75R1 is a mutactimycin derivative produced by Nocardia brasiliensis. It inhibits gram-positive bacteria with MIC of 0.2-3.1 μg/mL, and inhibits L1210 cell with ED50 of 7.4 μg/mL.

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Synonyms SO 75R1; SO-075R1
IUPAC Name 6,9,11-trihydroxy-7-(3-hydroxy-4,5-dimethoxy-6-methyloxan-2-yl)oxy-4-methoxy-3,9-dimethyl-8,10-dihydro-7H-tetracene-5,12-dione
Canonical SMILES CC1C(C(C(C(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=C(C=C5)C)OC)O)(C)O)O)OC)OC
InChI InChI=1S/C29H34O11/c1-11-7-8-13-17(25(11)36-4)23(33)19-18(20(13)30)21(31)14-9-29(3,35)10-15(16(14)22(19)32)40-28-24(34)27(38-6)26(37-5)12(2)39-28/h7-8,12,15,24,26-28,31-32,34-35H,9-10H2,1-6H3
InChI Key BOCNMPJNEZKZFJ-UHFFFAOYSA-N
Appearance Orange Crystal
Antibiotic Activity Spectrum Gram-positive bacteria
Melting Point 121-122°C
1. The producer and biological activities of SO-75R1, a new mutactimycin group antibiotic [corrected]
A Maeda, K Yazawa, Y Mikami, M Ishibashi, J Kobayashi J Antibiot (Tokyo). 1992 Dec;45(12):1848-52. doi: 10.7164/antibiotics.45.1848.
The producer of SO-75R1, a new anthracycline group antibiotic was identified as Nocardia brasiliensis. SO-75R1 was active against Gram-positive bacteria, but not active against Gram-negative bacteria or fungi. All tested Nocardia brasiliensis strains as well as the producer itself were resistant to SO-75R1, although four other pathogenic Nocardia, i.e. N. asteroides, N. nova, N. farcinica and N. otitidiscaviarum were sensitive [corrected].

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