Spiro-Oxanthromicin A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-05246 |
| CAS | 1616622-10-6 |
| Molecular Weight | 618.58 |
| Molecular Formula | C36H26O10 |
| Purity | ≥95% by HPLC |
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Description
Spiro-Oxanthromicin A is a polyketide first isolated from a soil-derived Streptomyces sp. Spiro-Oxanthromicin A inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells. It inhibits Bacillus cereus but has no activity against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi.
Specification
| Synonyms | Oxanthromicin A, spiro; (±)-spiro-oxanthromicin A; 2',7'-dihydro-2,5,6',10'-tetrahydroxy-4,5',6,8'-tetramethyl-7',10-dioxo-spiro[anthracene-9(10H),3'-[3H]benz[de]anthracene]-3,9'-dicarboxylic acid; 2,5,6',10'-tetrahydroxy-4,5',6,8'-tetramethyl-7',10-dioxo-2',7'-dihydro-10H-spiro[anthracene-9,3'-benzo[de]anthracene]-3,9'-dicarboxylic acid |
| Storage | Store at -20°C |
| IUPAC Name | 3',6,8',10-tetrahydroxy-1',5,7',8-tetramethyl-7,9'-dioxospiro[2H-benzo[a]phenalene-3,10'-anthracene]-2',9-dicarboxylic acid |
| Canonical SMILES | CC1=C(C2=C(C=C1)C3(CC=C4C5=CC(=C(C(=C5C(=O)C6=C(C(=CC3=C46)C)O)C)C(=O)O)O)C7=CC(=C(C(=C7C2=O)C)C(=O)O)O)O |
| InChI | InChI=1S/C36H26O10/c1-12-5-6-18-28(30(12)39)33(42)24-15(4)26(35(45)46)22(38)11-20(24)36(18)8-7-16-17-10-21(37)25(34(43)44)14(3)23(17)32(41)29-27(16)19(36)9-13(2)31(29)40/h5-7,9-11,37-40H,8H2,1-4H3,(H,43,44)(H,45,46) |
| InChI Key | GLAYNHMYQPENCN-UHFFFAOYSA-N |
Properties
| Appearance | Solid |
| Antibiotic Activity Spectrum | Bacteria |
| Boiling Point | 908.4±65.0°C at 760 mmHg |
| Density | 1.7±0.1 g/cm3 |
| Solubility | Soluble in DMSO, Methanol |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
