Sporaricin C
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| Category | Antibiotics |
| Catalog number | BBF-02935 |
| CAS | 68743-80-6 |
| Molecular Weight | 432.52 |
| Molecular Formula | C18H36N6O6 |
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Description
It is an aminoglycoside antibiotic produced by the strain of Saccharopolyspora hirsuta subsp. kobensis KC-6606. It has anti-bacterial and mycobacterium effects, and the antibacterial effect of Sporaricin C is twice as strong as Sporaricin D.
Specification
| Synonyms | Antibiotic KA 6606III; KA-6606-III; D-allo-Inositol, 2-amino-5-((((aminocarbonyl)amino)acetyl)methylamino)-2,3,5-trideoxy-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-4-O-methyl- |
| IUPAC Name | N-[(1S,2R,3R,4R,6S)-4-amino-3-[(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxy-6-methoxycyclohexyl]-2-(carbamoylamino)-N-methylacetamide |
| Canonical SMILES | CC(C1CCC(C(O1)OC2C(CC(C(C2O)N(C)C(=O)CNC(=O)N)OC)N)N)N |
| InChI | InChI=1S/C18H36N6O6/c1-8(19)11-5-4-9(20)17(29-11)30-16-10(21)6-12(28-3)14(15(16)26)24(2)13(25)7-23-18(22)27/h8-12,14-17,26H,4-7,19-21H2,1-3H3,(H3,22,23,27)/t8-,9+,10+,11-,12-,14+,15+,16+,17+/m0/s1 |
| InChI Key | PUURLTDHGIJACO-WQCXHKNXSA-N |
Properties
| Appearance | Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; Mycobacteria |
| Boiling Point | 640.0°C at 760 mmHg |
| Melting Point | 145-152°C |
| Density | 1.30 g/cm3 |
| Solubility | Soluble in Methanol, Water, Ethanol |
Reference Reading
1. Syntheses of sporaricin analogues, 2-deoxy-4-N-glycyl-6-O-(alpha-nebrosaminyl)fortamine and its 3-de-O-methyl compound
T Yamaguchi, Y Kyotani, I Watanabe, S Sato, Y Takahashi, M Nagakura, T Mori J Antibiot (Tokyo). 1979 Nov;32(11):1137-46. doi: 10.7164/antibiotics.32.1137.
2-Deoxy-4-N-glycyl-6-O-(alpha-nebrosaminyl)fortamine (21) and 3-de-O-methyl-2-deoxy-4-N-glycyl-6-O-(alpha-nebrosaminyl)fortamine (27) were prepared starting from lividamine. The syntheses include four key steps, that is, transformation of 2-deoxystreptamine moiety of lividamine to 4-N,3-O-didemethyl-2-deoxyfortamine, selective 4-N-methylation of the new aminocyclitol moiety, selective attachment of a glycyl residue to the methylamino group at C-4 and selective amination at C-6'.
2. A new broad-spectrum aminoglycoside antibiotic complex, sporaricin. IV. Sporaricins C and D
T Deushi, I Watanabe, A Iwasaki, K Kamiya, T Mizoguchi, M Nakayama, M Okuchi, H Itoh, T Mori J Antibiot (Tokyo). 1981 Jul;34(7):811-7. doi: 10.7164/antibiotics.34.811.
Two new aminoglycoside antibiotics, sporaricins C and D have been isolated from the culture broth of Saccharopolyspora hirsuta subsp. kobensis, which produced sporaricins A and B. The structures of sporaricins C and D have been determined to be 4-N-carbamoyl-glycylsporaricin B and 4-N-formylglycylsporaricin B, respectively. Sporaricins C and D are active against Gram-negative and Gram-negative bacteria including aminoglycoside-resistant strains.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
