Sporaviridin
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02941 |
| CAS | 72497-34-8 |
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Description
It is produced by the strain of Streptosporangium viridogriseum. The mixture of Sporaviridin have anti-Gram-positive bacteria, yeast and psoriasis fungal activity, and each component also has the same antibacterial activity.
Properties
| Appearance | Amorphous Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Fungi; Yeast |
| Solubility | Soluble in Water, Methanol |
Reference Reading
1. Uncoupling action of antibiotic sporaviridins with rat-liver mitochondria
H Miyoshi, M Tamaki, K Harada, H Murata, M Suzuki, H Iwamura Biosci Biotechnol Biochem. 1992 Nov;56(11):1776-9. doi: 10.1271/bbb.56.1776.
The effects of the glycoside antibiotic sporaviridins (SVDs) on oxidative phosphorylation of rat-liver mitochondria were examined. SVDs released state 4 respiration, dissipated transmembrane electrical potential, and accelerated ATPase activity. These facts demonstrated that SVDs are potent uncouplers of oxidative phosphorylation. During the uncoupling caused by SVDs, large amplitude swelling and oxidation of intramitochondrial NAD(P)H occurred, suggesting that SVDs greatly enhanced nonspecific permeability of the inner mitochondrial membrane. It is suggested that the uncoupling action of SVDs might be caused by dissipation of proton electrochemical potential due to an increase in the permeability of inner mitochondrial membrane.
2. Structural investigation of the antibiotic sporaviridin. XIV. Isolation of components of intact sporaviridin
K Harada, I Kimura, T Sakazaki, H Murata, M Suzuki J Antibiot (Tokyo). 1989 Jul;42(7):1056-62. doi: 10.7164/antibiotics.42.1056.
Six components of sporaviridin (SVD) were successfully isolated by HPLC using methano-1 M ammonium chloride as the mobile phase. Each component possesses expectedly antimicrobial activity. To ensure the structural relationship between the intact SVD and N-acetylated sporaviridins (N-Ac-SVD), they were converted to the corresponding of N-acetates by acetylation in methanol, whose structures had already been determined as glycosides consisting of a 34-membered macrocyclic lactone, viridopentaoses, D-glucose and N-acetylvancosamine.
3. Structural elucidation of aculeximycin. III. Planar structure of aculeximycin, belonging to a new class of macrolide antibiotics
H Murata, K Suzuki, T Tabayashi, C Hattori, Y Takada, K Harada, M Suzuki, T Ikemoto, T Shibuya, T Haneishi, et al. J Antibiot (Tokyo). 1995 Aug;48(8):838-49. doi: 10.7164/antibiotics.48.838.
The planar structure of aculeximycin (1) produced by Streptosporangium albidum has been determined by spectral methods and chemical degradations such as 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU)-methanol reaction, ozonolysis, and periodative oxidation. The antibiotic consists of a 30-membered polyhydroxy lactone ring, an alpha, beta-unsaturated ester group, an intramolecular hemiketal, an oligosaccharide (aculexitriose), a neutral sugar and an amino sugar. The structure of aculeximycin is closely related to those of sporaviridins produced by Streptosporangium viridogriseum. We consider that aculeximycin and sporaviridins belong to a new class of macrolide antibiotics, which is different from the polyol macrolides produced by Streptomyces.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
