Sporostatin

Name: Sporostatin
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Enzyme inhibitors
Catalog number	BBF-02940
CAS
Molecular Weight	262.26
Molecular Formula	C14H14O5

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Sporormiella sp. M5032. It inhibits cAMP-PDE with ID50 of 41 μg/mL. 1000 μg/mL of Sporostatin has no effect on Gram-positive bacteria, Gram-negative bacteria and Candida albicans.

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Synonyms	(+)-Sporostatin
IUPAC Name	(4S,6E)-9,11-dihydroxy-4-methyl-4,5-dihydro-1H-3-benzoxecine-2,8-dione
Canonical SMILES	CC1CC=CC(=O)C2=C(CC(=O)O1)C=C(C=C2O)O
InChI	InChI=1S/C14H14O5/c1-8-3-2-4-11(16)14-9(6-13(18)19-8)5-10(15)7-12(14)17/h2,4-5,7-8,15,17H,3,6H2,1H3/b4-2+/t8-/m0/s1
InChI Key	UCKXWYAPJJITRZ-KHVHVRLGSA-N

Appearance	Pale Yellow Crystal
Melting Point	187-200°C
Solubility	Soluble in Methanol

1. Sporostatin, a novel and specific inhibitor of EGF receptor kinase

Y Murakami, A Ishii, S Mizuno, S Yaginuma, Y Uehara Anticancer Res. 1999 Sep-Oct;19(5B):4145-9.

Sporostatin isolated from a fungus of Sporormiella sp.M5032 as an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was found to be a specific inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase in vitro. Its IC50 values were 0.1 microgram/ml (0.38 microM) for EGF receptor kinase, 3 micrograms/ml (11 microM) for ErbB-2, and 100 micrograms/ml (380 microM) or more than that for other kinases including PDGF receptor, v-src and protein kinase C. Kinetic analyses revealed that inhibition of EGF receptor kinase by sporostatin was noncompetitive either with substrate or with ATP. Autophosphorylation of EGF receptor in A431 cells was also inhibited. These results show that sporostatin is a potent and specific inhibitor of EGF receptor kinase.

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