Sporostatin
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02940 |
| CAS | |
| Molecular Weight | 262.26 |
| Molecular Formula | C14H14O5 |
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Description
It is produced by the strain of Sporormiella sp. M5032. It inhibits cAMP-PDE with ID50 of 41 μg/mL. 1000 μg/mL of Sporostatin has no effect on Gram-positive bacteria, Gram-negative bacteria and Candida albicans.
Specification
| Synonyms | (+)-Sporostatin |
| IUPAC Name | (4S,6E)-9,11-dihydroxy-4-methyl-4,5-dihydro-1H-3-benzoxecine-2,8-dione |
| Canonical SMILES | CC1CC=CC(=O)C2=C(CC(=O)O1)C=C(C=C2O)O |
| InChI | InChI=1S/C14H14O5/c1-8-3-2-4-11(16)14-9(6-13(18)19-8)5-10(15)7-12(14)17/h2,4-5,7-8,15,17H,3,6H2,1H3/b4-2+/t8-/m0/s1 |
| InChI Key | UCKXWYAPJJITRZ-KHVHVRLGSA-N |
Properties
| Appearance | Pale Yellow Crystal |
| Melting Point | 187-200°C |
| Solubility | Soluble in Methanol |
Reference Reading
1. Sporostatin, a novel and specific inhibitor of EGF receptor kinase
Y Murakami, A Ishii, S Mizuno, S Yaginuma, Y Uehara Anticancer Res. 1999 Sep-Oct;19(5B):4145-9.
Sporostatin isolated from a fungus of Sporormiella sp.M5032 as an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was found to be a specific inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase in vitro. Its IC50 values were 0.1 microgram/ml (0.38 microM) for EGF receptor kinase, 3 micrograms/ml (11 microM) for ErbB-2, and 100 micrograms/ml (380 microM) or more than that for other kinases including PDGF receptor, v-src and protein kinase C. Kinetic analyses revealed that inhibition of EGF receptor kinase by sporostatin was noncompetitive either with substrate or with ATP. Autophosphorylation of EGF receptor in A431 cells was also inhibited. These results show that sporostatin is a potent and specific inhibitor of EGF receptor kinase.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
