Stauprimide
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| Category | Enzyme inhibitors |
| Catalog number | BBF-04444 |
| CAS | 154589-96-5 |
| Molecular Weight | 584.62 |
| Molecular Formula | C35H28N4O5 |
| Purity | >98% |
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Description
It is produced by the strain of Streptomyces. Stauprimide is an enhancer of embryonic stem cell differentiation into endoderm. It inhibits nuclear translocation of NME2.
Specification
| Synonyms | N-Benzoyl-7-oxostaurosporine; N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide |
| Storage | Store at -20°C |
| IUPAC Name | N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide |
| Canonical SMILES | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC |
| InChI | InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1 |
| InChI Key | MQCCJEYZKWZQHU-MPRCCEKMSA-N |
| Source | Streptomyces sp. |
Properties
| Appearance | Yellow Orange Solid |
| Density | 1.52±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in Ethanol, Methanol, DMF, DMSO |
Reference Reading
1.Stauprimide Priming of Human Embryonic Stem Cells toward Definitive Endoderm.
Tahamtani Y1, Azarnia M1, Farrokhi A2, Moradmand A2, Mirshahvaladi S2, Aghdami N2, Baharvand H2. Cell J. 2014 Feb 3;16(1):63-72. Epub 2014 Feb 3.
OBJECTIVE: In vitro production of a definitive endoderm (DE) is an important issue in stem cell-related differentiation studies and it can assist with the production of more efficient endoderm derivatives for therapeutic applications. Despite tremendous progress in DE differentiation of human embryonic stem cells (hESCs), researchers have yet to discover universal, efficient and cost-effective protocols.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
