Strobilurin H

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Category Antibiotics
Catalog number BBF-03082
CAS 129145-65-9
Molecular Weight 288.34
Molecular Formula C17H20O4

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Description

Strobilurin H is an antibiotic produced by Bolina lutea Sacc. It has strong anti-fungal activity, and its in vitro anti-tumor proliferation IC50 is 2.5 µmol/L.

Specification

IUPAC Name methyl (2E,3Z,5E)-2-(methoxymethylidene)-6-(3-methoxyphenyl)-3-methylhexa-3,5-dienoate
Canonical SMILES CC(=CC=CC1=CC(=CC=C1)OC)C(=COC)C(=O)OC
InChI InChI=1S/C17H20O4/c1-13(16(12-19-2)17(18)21-4)7-5-8-14-9-6-10-15(11-14)20-3/h5-12H,1-4H3/b8-5+,13-7-,16-12+
InChI Key MTTZSOSUZLNSSO-PLJMREBYSA-N

Properties

Appearance Yellow Oil
Antibiotic Activity Spectrum fungi; neoplastics (Tumor)
Boiling Point 447.9°C at 760 mmHg
Density 1.081 g/cm3

Reference Reading

1. Strobilurins F, G and H, three new antifungal metabolites from Bolinea lutea. I. Fermentation, isolation and biological activity
A Fredenhagen, A Kuhn, H H Peter, V Cuomo, U Giuliano J Antibiot (Tokyo). 1990 Jun;43(6):655-60. doi: 10.7164/antibiotics.43.655.
Three new strobilurins F, G and H, antibiotics with antifungal activity, were isolated from cultures of Bolinea lutea Sacc. These new compounds differ from previously described analogs in their aromatic substitution. An HPLC method allows complete separation of all the components.

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