Subsphaeric acid
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| Category | Others |
| Catalog number | BBF-04915 |
| CAS | 120091-90-9 |
| Molecular Weight | 388.41 |
| Molecular Formula | C21H24O7 |
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Description
Subsphaeric acid is a depside from dimelaena lichens.
Specification
| IUPAC Name | 2-hydroxy-4-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-6-pentylbenzoic acid |
Reference Reading
1. Antioxidant activity and enzymatic of lichen substances: A study based on cyclic voltammetry and theoretical
Osvaldo Yañez, Manuel I Osorio, Edison Osorio, William Tiznado, Lina Ruíz, Camilo García, Orlando Nagles, Mario J Simirgiotis, Grover Castañeta, Carlos Areche, Olimpo García-Beltrán Chem Biol Interact. 2023 Feb 25;372:110357. doi: 10.1016/j.cbi.2023.110357. Epub 2023 Jan 21.
The antioxidant activity of nine lichen substances, including methylatrarate (1), methyl haematommate (2), lobaric acid (3), fumarprotocetraric acid (4), sphaerophorin (5), subsphaeric acid (6), diffractaic acid (7), barbatolic acid (8) and salazinic acid (9) has been determined through cyclic voltammetry. The compounds 1-4 presented slopes close to the Nernst constant of 0.059 V, indicating a 2H+/2e- relation between protons and electrons, as long as the compounds 5, 6, 7, 8, and 9 present slopes between 0.037 V and 0.032 V, indicating a 1H+/2e- relation between protons and electrons. These results show a high free radical scavenging activity by means of the release of H+, suggesting an important antioxidant capacity of these molecules. Theoretical calculations of hydrogen bond dissociation enthalpies (BDE), proton affinities (PA), and Proton Transfer (PT) mechanisms, at M06-2x/6-311+G(d,p) level complement the experimental results. Computations support that the best antioxidant activity is obtained for the molecules (3, 4, 5, 6, 7 and 8), that have a carboxylic acid group close to a phenolic hydroxyl group, through hydrogen atomic transfer (HAT) and sequential proton loss electron transfer (SPLET) mechanisms. Additional computations were performed for modelling binding affinity of the lichen substances with CYPs enzymes, mainly CYP1A2, CYP51, and CYP2C9*2 isoforms, showing strong affinity for all the compounds described in this study.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
