Sulfadiazine
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| Category | Antibiotics |
| Catalog number | BBF-04517 |
| CAS | 68-35-9 |
| Molecular Weight | 250.28 |
| Molecular Formula | C10H10N4O2S |
| Purity | >98% |
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Description
Sulfadiazine is a sulfonamide antibiotic. It has activity against both Gram-positive and Gram-negative bacteria.
Specification
| Synonyms | RP-2616; RP2616; RP 2616; Liquadiazine; Microsulfon; 2-(4-Aminobenzenesulfonamido)pyrimidine; 2-Sulfanilylaminopyrimidine; Adiazin; Adiazine; Debenal; Sulfolex; Sulphadiazine; Theradiazine |
| Storage | Store at 2-8°C protect from light |
| IUPAC Name | 4-amino-N-pyrimidin-2-ylbenzenesulfonamide |
| Canonical SMILES | C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N |
| InChI | InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) |
| InChI Key | SEEPANYCNGTZFQ-UHFFFAOYSA-N |
| Source | Synthetic |
Properties
| Appearance | White Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 512.6±52.0°C (Predicted) |
| Melting Point | 252-256°C |
| Flash Point | 263.8°C |
| Density | 1.496 g/cm3 |
| Solubility | Slightly soluble in DMSO, Methanol |
Reference Reading
1.Comparative evaluation of therapeutic efficacy of sulfadiazine-trimethoprim, oxytetracycline, enrofloxacin and florfenicol on Staphylococcus aureus-induced arthritis in broilers.
Mosleh N1, Shomali T1, Namazi F2, Marzban M1, Mohammadi M1, Boroojeni AM2. Br Poult Sci. 2016 Apr;57(2):179-84. doi: 10.1080/00071668.2016.1148263.
Staphylococcus aureus is an important human and veterinary pathogen that causes economic loss in the poultry industry. This study aimed to compare therapeutic efficacy of 4 commonly used antibiotics in poultry on S. aureus-induced arthritis in broilers. Sixty broilers, 8 weeks of age, were assigned at random into 7 groups as follows: (1) negative control (n = 5); (2) vehicle control (n = 5); (3) sulfadiazine-trimethoprim, 250 ml/1000 l drinking water (n = 10); (4) oxytetracycline 20%, 1 mg/l drinking water (n = 10); (5) florfenicol 10%, 1/1000 v/v in drinking water (n = 10); (6) enrofloxacin 10%, 1/1000 v/v in drinking water (n = 10) and (7) positive control (n = 10). Birds in group 2 were injected with 1 ml of sterile TSB medium into the right tibiotarsal joint on d 0 while other birds (except group 1) were challenged with 1 ml of 1.2 × 10(10) CFU/ml suspension of S. aureus bacteria. Antibiotic therapy was started from d 4 post challenge and continued for 5 d.
2.Antimicrobial Wound Dressing Containing Silver Sulfadiazine With High Biocompatibility: In Vitro Study.
Mohseni M1, Shamloo A1, Aghababaei Z2, Vossoughi M2, Moravvej H3. Artif Organs. 2016 Apr 20. doi: 10.1111/aor.12682. [Epub ahead of print]
Many patients all over the world suffer from acute wounds caused by traumas or burns. In most crucial cases, skin regeneration cannot be promoted spontaneously, and skin grafts are applied as the main treatment. However, this therapy has some drawbacks which motivate researchers to develop wound dressings. In this study, electrospun mats consisting of polycaprolactone (PCL) and polyvinyl alcohol (PVA) incorporated with silver sulfadiazine (SSD) are proposed to be used as antimicrobial wound dressings with the capability of cell seeding. Various amounts of SSD were loaded into PVA nanofibers, and the effects of SSD particles on the morphological characteristics of nanofibers, mechanical behaviors, and physical properties of the mats were studied for the first time. The cellular viability, antimicrobial properties of the scaffolds, and release behavior of silver were also examined. Finally, the best concentration of SSD was determined based on the quality of nanofibers, antibacterial features, and the ability of cellular attachment and proliferation.
3.The role of silver sulphadiazine in the conservative treatment of partial thickness burn wounds: A systematic review.
Heyneman A1, Hoeksema H2, Vandekerckhove D2, Pirayesh A2, Monstrey S2. Burns. 2016 Apr 25. pii: S0305-4179(16)30056-0. doi: 10.1016/j.burns.2016.03.029. [Epub ahead of print]
BACKGROUND: For more than 40 years, silver sulphadiazine 1% (SSD) is considered as standard therapy for the conservative treatment of burn wounds. However, in the last 10 years, substantial disadvantages of SSD have been reported in the literature and probably as a result of this, several new dressings for burn wounds have been developed and put on the market. The objective of this systematic review is to evaluate the available evidence on SSD in the conservative treatment of burns, specifically in comparison with the newer burn dressings that are increasingly being used nowadays.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
