Sulfamonomethoxine
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| Category | Enzyme inhibitors |
| Catalog number | BBF-04518 |
| CAS | 1220-83-3 |
| Molecular Weight | 280.30 |
| Molecular Formula | C11H12N4O3S |
| Purity | ≥93% |
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Description
Sulfamonomethoxine, a sulfonamide derivative, is an antibacterial agent commonly used as a veterinary drug. It is also an enzyme inhibitor used to address hyperpyrexia.
Specification
| Synonyms | Sulfamonomethoxin; Daimeton; Sulfamonomethoxinum; 4-Methoxy-6-sulfanilamidopyrimidine; 4-Sulfanilamido-6-methoxypyrimidine; 6-Methoxy-4-sulfanilamidopyrimidine; N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide; Ro 4-3476 |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage | Store at 2-8°C |
| IUPAC Name | 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide |
| Canonical SMILES | COC1=NC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N |
| InChI | InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15) |
| InChI Key | WMPXPUYPYQKQCX-UHFFFAOYSA-N |
| Source | Semi-synthetic |
Properties
| Appearance | White to Off-white Solid |
| Application | Anti-Infective Agents |
| Antibiotic Activity Spectrum | Bacteria |
| Boiling Point | 513.2°C at 760 mmHg |
| Melting Point | 203-206°C |
| Density | 1.465 g/cm3 |
| Solubility | Slightly soluble in DMSO, Methanol |
Reference Reading
1.[Sulfanilamide absorption and acetylation in rats with experimental hyperlipidemia and cellular regulation of the process of acetylation].
Makarov VA;Vasilenko IuK;Suetina IV;Vaskanian VL;Lubiankina SV Farmakol Toksikol. 1981 Jan-Feb;44(1):109-15.
Experiments on an isolated ileum of the rat with experimental hyperlipidemia have shown the decreased acetylation rate of sulfalen, sulfamonomethoxin and sulfapyridazine. The absorption rate of the free forms of sulfanilamides was increased (significantly for sulfalen and sulfapyridazine). Isadrin (1 . 10(-8) M) and cAMP (1 . 10(-5) M) introduced into the liquid exposed to the mucosa of the rat ileum raised the acetylation rate of sulfamonomethoxin by the ileic wall while anaprilin (1 . 10(-6) M) led to the reduction of both absorption and acetylation of this sulfanilamide. Addition of cAMP to the incubation mixture of mitochondria and microsomes increased the acetylation rate of sulfamonomethoxin.
2.Determination of sulfonamide residues in eggs by liquid chromatography.
Furusawa N J AOAC Int. 2002 Jul-Aug;85(4):848-52.
A method was developed for determining residual sulfonamide antibacterials such as sulfamethazine (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM), and sulfaquinoxaline (SQ) in eggs using liquid chromatography with a photodiode array detector. The spiked and blank samples were cleaned up by using an Ultrafree-MC/PL centrifugal ultrafiltration unit. A Mightysil RP-4 GP column and a mobile phase of 28% (v/v) ethanol-H2O with a photodiode array detector were used for the determination. Average recoveries from eggs spiked with each drug at 0.1, 0.2, 0.4, and 1.0 ppm were > or = 80.9%, with relative standard deviations between 1.3 and 4.7%. The limits of quantitation were 0.060 ppm for SMZ, 0.045 for SMM, 0.044 for SDM, and 0.093 for SQ. The analysis of one sample required < 30 min and < 5 mL ethanol as solvent.
3.Liquid chromatographic determination of multiple sulfonamides, nitrofurans, and chloramphenicol residues in pasteurized milk.
Perez N;Gutierrez R;Noa M;Diaz G;Luna H;Escobar I;Munive Z J AOAC Int. 2002 Jan-Feb;85(1):20-4.
A rapid and selective liquid chromatographic method was developed to detect 6 sulfonamides, 3 nitrofurans, and chloramphenicol residues in pasteurized milk. The 10 drugs were extracted with chloroform-acetone and the organic phase was evaporated; the residues were dissolved in an aqueous sodium acetate buffer solution 0.02M (pH = 4.8), and the fat was removed by washing with hexane. The aqueous layer was collected, filtered, and injected. The 6 sulfonamides and chloramphenicol were detected at 275 nm ultraviolet (UV) using a gradient system starting with sodium acetate buffer solution-acetonitrile (95 + 5) and finishing with sodium acetate buffer solution-acetonitrile (80 + 20). Nitrofurans were detected at 375 nm (UV) isocratically with sodium acetate buffer solution-acetonitrile (80 + 20). For 50 ppb fortified milk, the average recoveries were (sulfathiazole) 65.52%; (sulfamerazine) 75.36%; (sulfamethazine) 93.94%; (sulfachlorpyridazine) 75.94%; (sulfamethoxazole) 85.18%; (sulfamonomethoxine) 83.45%; (chloramphenicol) 104.17%; (nitrofurazone) 91.81%; (furazolidone) 100.76%; and (furaltadone) 72.38%. Method detection limits ranged from 4 ppb (nitrofurazone) to 16 ppb (sulfamethazine).
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
