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SW-163C

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Category Mycotoxins
Catalog number BBF-02488
CAS
Molecular Weight 1113.2
Molecular Formula C52H60N10O14S2

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

SW-163C is an antitumor depsipeptide produced by Streptomyces sp. SNA15896. The LD50 of SW-163C is > 100 mg/kg.

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Synonyms SW-163 C
Canonical SMILES CC1CC12C(=O)OCC(C(=O)NC(C(=O)N(C3CSSCC(C(=O)N2C)N(C(=O)C(NC(=O)C(COC(=O)C4(CC4C)N(C3=O)C)NC(=O)C5=NC6=CC=CC=C6C=C5O)C)C)C)C)NC(=O)C7=NC8=CC=CC=C8C=C7O
InChI InChI=1S/C52H60N10O14S2/c1-25-19-51(25)49(73)75-21-33(57-43(67)39-37(63)17-29-13-9-11-15-31(29)55-39)41(65)53-28(4)46(70)60(6)36-24-78-77-23-35(47(71)61(51)7)59(5)45(69)27(3)54-42(66)34(22-76-50(74)52(20-26(52)2)62(8)48(36)72)58-44(68)40-38(64)18-30-14-10-12-16-32(30)56-40/h9-18,25-28,33-36,63-64H,19-24H2,1-8H3,(H,53,65)(H,54,66)(H,57,67)(H,58,68)
InChI Key LWKICZFLUHYJAT-UHFFFAOYSA-N
Antibiotic Activity Spectrum neoplastics (Tumor)
1. SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. II. Structure elucidation
K Takahashi, H Koshino, Y Esumi, E Tsuda, K Kurosawa J Antibiot (Tokyo). 2001 Aug;54(8):622-7. doi: 10.7164/antibiotics.54.622.
SW-163C and E are novel antitumor antibiotics, which belong to quinomycin family, isolated from the culture broth of Streptomyces sp. SNA15896. These compounds were determined to be cyclic depsipeptides having 3-hydroxyquinaldic acid as a chromophore and a sulfur-containing intramolecular cross linkage through various spectroscopic analyses.
2. SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. I. Taxonomy, fermentation, isolation and biological activities
K Kurosawa, K Takahashi, E Tsuda J Antibiot (Tokyo). 2001 Aug;54(8):615-21. doi: 10.7164/antibiotics.54.615.
Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.
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