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TA-3037A

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Category Enzyme inhibitors
Catalog number BBF-02490
CAS 143651-44-9
Molecular Weight 281.26
Molecular Formula C16H11NO4

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Fermentation Lab

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Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

TA-3037A is a glutathione S-transferase inhibitor isolated from the fermentation broth of Streptomyces sp. TA-3037.

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Synonyms TA 3037A; (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid
IUPAC Name (3Z)-3-benzylidene-2-oxo-4H-1,4-benzoxazine-5-carboxylic acid
Canonical SMILES C1=CC=C(C=C1)C=C2C(=O)OC3=CC=CC(=C3N2)C(=O)O
InChI InChI=1S/C16H11NO4/c18-15(19)11-7-4-8-13-14(11)17-12(16(20)21-13)9-10-5-2-1-3-6-10/h1-9,17H,(H,18,19)/b12-9-
InChI Key INMSMQQFIAUCNQ-XFXZXTDPSA-N
Appearance Yellow Needle Crystal
Melting Point 248-250°C (dec.)
Solubility Soluble in DMF, THF, dioxane, slightly soluble in ethanol.
1. TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. II. Structure determination
D Komagata, Y Muraoka, R Sawa, Y Takahashi, H Naganawa, T Sawa, T Takeuchi J Antibiot (Tokyo). 1992 Jul;45(7):1122-4. doi: 10.7164/antibiotics.45.1122.
TA-3037A, a new inhibitor of glutathione S-transferase, has been isolated from the culture broth of Streptomyces sp. TA-3037. The structure of TA-3037A was defined as (Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid by an analysis of spectral properties and chemical studies of TA-3037A and its derivatives.
2. TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. I. Production, isolation, physico-chemical properties and biological activities
D Komagata, T Sawa, Y Muraoka, C Imada, Y Okami, T Takeuchi J Antibiot (Tokyo). 1992 Jul;45(7):1117-21. doi: 10.7164/antibiotics.45.1117.
TA-3037A, a new inhibitor of glutathione S-transferase was discovered in the fermentation broth of Streptomyces sp. TA-3037. It was purified by chromatography followed by solvent extraction and then isolated as yellow needles. TA-3037A has the molecular formula of C16H11NO4. It was competitive with the substrate, and the inhibition constant (Ki) was 4.9 microM.

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