TA-3037A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02490 |
| CAS | 143651-44-9 |
| Molecular Weight | 281.26 |
| Molecular Formula | C16H11NO4 |
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Description
TA-3037A is a glutathione S-transferase inhibitor isolated from the fermentation broth of Streptomyces sp. TA-3037.
Specification
| Synonyms | TA 3037A; (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid |
| IUPAC Name | (3Z)-3-benzylidene-2-oxo-4H-1,4-benzoxazine-5-carboxylic acid |
| Canonical SMILES | C1=CC=C(C=C1)C=C2C(=O)OC3=CC=CC(=C3N2)C(=O)O |
| InChI | InChI=1S/C16H11NO4/c18-15(19)11-7-4-8-13-14(11)17-12(16(20)21-13)9-10-5-2-1-3-6-10/h1-9,17H,(H,18,19)/b12-9- |
| InChI Key | INMSMQQFIAUCNQ-XFXZXTDPSA-N |
Properties
| Appearance | Yellow Needle Crystal |
| Melting Point | 248-250°C (dec.) |
| Solubility | Soluble in DMF, THF, dioxane, slightly soluble in ethanol. |
Reference Reading
1. TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. II. Structure determination
D Komagata, Y Muraoka, R Sawa, Y Takahashi, H Naganawa, T Sawa, T Takeuchi J Antibiot (Tokyo). 1992 Jul;45(7):1122-4. doi: 10.7164/antibiotics.45.1122.
TA-3037A, a new inhibitor of glutathione S-transferase, has been isolated from the culture broth of Streptomyces sp. TA-3037. The structure of TA-3037A was defined as (Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid by an analysis of spectral properties and chemical studies of TA-3037A and its derivatives.
2. TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. I. Production, isolation, physico-chemical properties and biological activities
D Komagata, T Sawa, Y Muraoka, C Imada, Y Okami, T Takeuchi J Antibiot (Tokyo). 1992 Jul;45(7):1117-21. doi: 10.7164/antibiotics.45.1117.
TA-3037A, a new inhibitor of glutathione S-transferase was discovered in the fermentation broth of Streptomyces sp. TA-3037. It was purified by chromatography followed by solvent extraction and then isolated as yellow needles. TA-3037A has the molecular formula of C16H11NO4. It was competitive with the substrate, and the inhibition constant (Ki) was 4.9 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
