TAN-1057D
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| Category | Antibiotics |
| Catalog number | BBF-02498 |
| CAS | 128126-47-6 |
| Molecular Weight | 355.4 |
| Molecular Formula | C13H25N9O3 |
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Description
TAN-1057D is an antibiotic produced by Flexibacter sp. PK-74 and PK-176. It is active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus.
Specification
| Synonyms | Antibiotic TAN 1057D; TAN 1057D |
| IUPAC Name | [(E)-[[(2S,5S)-5-[3-(diaminomethylideneamino)propyl]-1-methyl-3,7-dioxo-1,4-diazepan-2-yl]methylhydrazinylidene]methyl]urea |
| Canonical SMILES | CN1C(C(=O)NC(CC1=O)CCCN=C(N)N)CNN=CNC(=O)N |
| InChI | InChI=1S/C13H25N9O3/c1-22-9(6-19-20-7-18-13(16)25)11(24)21-8(5-10(22)23)3-2-4-17-12(14)15/h7-9,19H,2-6H2,1H3,(H,21,24)(H4,14,15,17)(H3,16,18,20,25)/t8-,9-/m0/s1 |
| InChI Key | PNFFUPQADHHLMN-IUCAKERBSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
Reference Reading
1. Synthesis and antimicrobial evaluation of TAN-1057A/B analogs
R M Williams, C Yuan, V J Lee, S Chamberland J Antibiot (Tokyo). 1998 Feb;51(2):189-201. doi: 10.7164/antibiotics.51.189.
TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.
2. TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity
N Katayama, S Fukusumi, Y Funabashi, T Iwahi, H Ono J Antibiot (Tokyo). 1993 Apr;46(4):606-13. doi: 10.7164/antibiotics.46.606.
Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
