Tetrocarcin E2
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| Category | Others |
| Catalog number | BBF-03113 |
| CAS | 83259-66-9 |
| Molecular Weight | 955.05 |
| Molecular Formula | C49H66N2O17 |
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Description
Tetrocarcin E2 is a small component produced by Micromonospora chalcea KY 11091. It has gram-positive bacterial activity, moderate activity against Bacillus subtilis, and weaker activity against Staphylococcus.
Specification
| Synonyms | Tetronolide, 9-O-(3-O-acetyl-2,6-dideoxy-alpha-L-ribo-hexopyranosyl)-17-O-(2,3,4,6-tetradeoxy-4-((methoxycarbonyl)amino)-3-C-methyl-3-nitro-beta-D-xylo-hexopyranosyl)- |
| IUPAC Name | [(2S,3S,4R,6R)-6-[[(5S,6R,7E,9S,10E,13S,16S,17S,18S,20S,21R,22R,23E)-3-formyl-5,23-dihydroxy-9-[(2R,4S,5R,6R)-5-(methoxycarbonylamino)-4,6-dimethyl-4-nitrooxan-2-yl]oxy-8,12,18,20,22-pentamethyl-25,27-dioxo-26-oxapentacyclo[22.2.1.01,6.013,22.016,21]heptacosa-3,7,10,14,23-pentaen-17-yl]oxy]-3-hydroxy-2-methyloxan-4-yl] acetate |
| Canonical SMILES | CC1CC(C(C2C1C3(C(C=C2)C(C=CC(C(=CC4C(C=C(CC45C(=O)C(=C3O)C(=O)O5)C=O)O)C)OC6CC(C(C(O6)C)NC(=O)OC)(C)[N+](=O)[O-])C)C)OC7CC(C(C(O7)C)O)OC(=O)C)C |
| InChI | InChI=1S/C49H66N2O17/c1-22-11-14-34(66-37-20-47(8,51(60)61)42(27(6)64-37)50-46(59)62-10)23(2)16-32-33(54)17-29(21-52)19-49(32)44(57)38(45(58)68-49)43(56)48(9)31(22)13-12-30-39(48)24(3)15-25(4)41(30)67-36-18-35(65-28(7)53)40(55)26(5)63-36/h11-14,16-17,21-22,24-27,30-37,39-42,54-56H,15,18-20H2,1-10H3,(H,50,59)/b14-11+,23-16+,43-38+/t22?,24-,25-,26-,27+,30-,31-,32+,33-,34-,35+,36-,37-,39+,40-,41-,42-,47-,48+,49?/m0/s1 |
| InChI Key | CJWOJYUQTRKAKJ-OZSDZKHESA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 1005.0±65.0°C at 760 mmHg |
| Melting Point | 205-208°C |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. Tetrocarcins E1, E2, F and F-1, new antibiotics. Fermentation, isolation and characterization
T Tamaoki, M Kasai, K Shirahata, F Tomita J Antibiot (Tokyo). 1982 Aug;35(8):979-84. doi: 10.7164/antibiotics.35.979.
New components of tetrocarcins (E1, E2, F and F-1) were found in the culture broth of Micromonospora chalcea KY 11091 that was known to produce tetrocarcins A, B and C. Tetrocarcin F-1 consisted of tetronolide and nitro sugar (tetronitrose). Tetrocarcins E1 and E2 consisted of F-1 and deoxy sugar (L-digitoxose). Tetrocarcin F consisted of F-1 and two deoxy sugars (their structures were not yet determined). They all showed antibacterial activities against Gram-positive bacteria and the specific activity decreased with decrease in the numbers of deoxy sugars attached to the aglycone.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
