Tetromycin A
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| Category | Antibiotics |
| Catalog number | BBF-04584 |
| CAS | 180027-83-2 |
| Molecular Weight | 576.76 |
| Molecular Formula | C36H48O6 |
| Purity | >99% by HPLC |
Online Inquiry
Description
An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway.
Specification
| Synonyms | [1S-(1R*,4R*,4aR*,6aS*,7E,11E,12aS*,15S*,16aR*,20aR*,20bS*)]-4-(acetyloxy)-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,6,7,11,12a,14,15,20a-octamethyl-18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione; 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide 9-Acetate |
| Storage | Store at -20°C |
| IUPAC Name | [(1S,3R,6R,7Z,11Z,13R,16S,17S,20S,21R,22S,23Z)-23-hydroxy-3,4,6,8,12,14,20,22-octamethyl-25,27-dioxo-26-oxapentacyclo[22.2.1.01,6.013,22.016,21]heptacosa-4,7,11,14,23-pentaen-17-yl] acetate |
| Canonical SMILES | CC1CCC(C2C1C3(C(C(=CCCC(=CC4(C=C(C(CC45C(=O)C(=C3O)C(=O)O5)C)C)C)C)C)C(=C2)C)C)OC(=O)C |
| InChI | InChI=1S/C36H48O6/c1-19-11-10-12-20(2)29-22(4)15-26-27(41-25(7)37)14-13-21(3)30(26)35(29,9)31(38)28-32(39)36(42-33(28)40)18-24(6)23(5)17-34(36,8)16-19/h12,15-17,21,24,26-27,29-30,38H,10-11,13-14,18H2,1-9H3/b19-16-,20-12-,31-28-/t21-,24+,26+,27-,29+,30+,34+,35+,36+/m0/s1 |
| InChI Key | MQEFCZZPPWNMPU-IWMYSMRLSA-N |
| Source | Streptomyces sp. |
Properties
| Appearance | Light Tan Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 684.1±55.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Ethanol, Methanol, DMF, DMSO; Moderate soluble in Water |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
