Thiazinotrienomycin A
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| Category | Antibiotics |
| Catalog number | BBF-03119 |
| CAS | 165337-93-9 |
| Molecular Weight | 707.87 |
| Molecular Formula | C38H49N3O8S |
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Description
Thiazinotrienomycin A is an ansa antibiotic produced by Str. sp. MJ672-m3. It has the effect of inhibiting cancer cells, and the IC50 for inhibiting HeLa cells is 5.0 ng/mL.
Specification
| IUPAC Name | (4Z,10E,14Z)-6,28-Dihydroxy-16-methoxy-5,7-dimethyl-18,24-dioxo-22-thia-19,25-diazatricyclo[18.7.1.0-21,26-]octacosa-1(28),4,10,12,14,20,26-heptaen-8-yl N-(1-cyclohexen-1-ylcarbonyl)alaninate |
| InChI | InChI=1S/C38H49N3O8S/c1-23-14-13-17-27-20-29-36(50-22-32(43)40-29)33(35(27)45)41-31(42)21-28(48-4)18-11-6-5-7-12-19-30(24(2)34(23)44)49-38(47)25(3)39-37(46)26-15-9-8-10-16-26/h5-7,11-12,14-15,18,20,24-25,28,30,34,44-45H,8-10,13,16-17,19,21-22H2,1-4H3,(H,39,46)(H,40,43)(H,41,42)/b6-5+,12-7+,18-11-,23-14- |
| InChI Key | SLZPTPUBMSQVAK-LCZHNUSPSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 899.3±65.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. Thiazinotrienomycins, new ansamycin group antibiotics
N Hosokawa, H Naganawa, H Inuma, M Hamada, T Takeuchi, T Kanbe, M Hori J Antibiot (Tokyo). 1995 Jun;48(6):471-8. doi: 10.7164/antibiotics.48.471.
New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. The structures and some biological and biochemical properties of the antibiotics were determined.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
