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Thiazinotrienomycin G

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Category Antibiotics
Catalog number BBF-03122
CAS
Molecular Weight 679.86
Molecular Formula C37H49N3O7S

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Thiazinotrienomycin G is an ansa antibiotic produced by Str. sp. MJ672-m3. It can inhibit the growth of tumor cells such as NCI-H522, NCI-H469, OVCAR-5, St-4 and BSY-1.

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IUPAC Name [(6E,8E,10E,16Z)-15,27-dihydroxy-5-methoxy-14,16-dimethyl-3-oxo-22-thia-2,24-diazatricyclo[18.6.1.021,25]heptacosa-1(27),6,8,10,16,20,23,25-octaen-13-yl] 2-(cyclohexanecarbonylamino)propanoate
Canonical SMILES CC1C(CC=CC=CC=CC(CC(=O)NC2=C(C(=C3C(=C2)N=CS3)CCC=C(C1O)C)O)OC)OC(=O)C(C)NC(=O)C4CCCCC4
InChI InChI=1S/C37H49N3O7S/c1-23-14-13-18-28-34(43)29(21-30-35(28)48-22-38-30)40-32(41)20-27(46-4)17-11-6-5-7-12-19-31(24(2)33(23)42)47-37(45)25(3)39-36(44)26-15-9-8-10-16-26/h5-7,11-12,14,17,21-22,24-27,31,33,42-43H,8-10,13,15-16,18-20H2,1-4H3,(H,39,44)(H,40,41)/b6-5+,12-7+,17-11+,23-14-
InChI Key XWXHOGFLJKTTBA-MHVOAVBDSA-N
Appearance White Powder
Antibiotic Activity Spectrum neoplastics (Tumor)
Boiling Point 850.3±65.0°C at 760 mmHg
Density 1.3±0.1 g/cm3
1. New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin
N Hosokawa, H Naganawa, M Hamada, H Iinuma, T Takeuchi, K S Tsuchiya, M Hori J Antibiot (Tokyo). 2000 Sep;53(9):886-94. doi: 10.7164/antibiotics.53.886.
New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.
2. Identification of AstG1, A LAL family regulator that positively controls ansatrienins production in Streptomyces sp. XZQH13
Chao Xie, Jing-Jing Deng, Hao-Xin Wang Curr Microbiol. 2015 Jun;70(6):859-64. doi: 10.1007/s00284-015-0798-6. Epub 2015 Mar 18.
Ansamycins is a group of type I polyketides characterized by the unique starter unit 3-amino-5-hydroxybenzoic acid. This family of secondary metabolites shows diverse biological activities, well-known members of which include rifamycin, geldanamycin, and maytansine. Previously, we isolated an AHBA synthase gene-positive strain Streptomyces sp. XZQH13 containing a "silent" ansamycin biosynthetic gene cluster ast. The constitutive expression of the Large-ATP-binding regulators of the LuxR family regulator gene astG1 located within the cluster triggered the expression of the biosynthetic genes. Reverse transcription-PCR experiments showed that the expression of the key biosynthetic genes, astB4, astD1, and astF1, was induced in the astG1 overexpression mutant compared to the wild type. This led to the isolation of two known ansatrienins, hydroxymycotrienin A (1) and thiazinotrienomycin G (2), which were identified by analysis of the mass spectral and NMR spectral data, from the mutant. These observations suggest that astG1 is probably a pathway-specific positive regulator for the biosynthesis of ansatrienin.

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