TMC-49A
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| Category | Bioactive by-products |
| Catalog number | BBF-02523 |
| CAS | |
| Molecular Weight | 221.29 |
| Molecular Formula | C13H19NO2 |
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Description
TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay.
Specification
| Synonyms | TMC-49 A; 2-phenylethyl n-butyl carbamate |
| IUPAC Name | butyl N-(2-phenylethyl)carbamate |
| Canonical SMILES | CCCCOC(=O)NCCC1=CC=CC=C1 |
| InChI | InChI=1S/C13H19NO2/c1-2-3-11-16-13(15)14-10-9-12-7-5-4-6-8-12/h4-8H,2-3,9-11H2,1H3,(H,14,15) |
| InChI Key | LUGMZFCJHLOENU-UHFFFAOYSA-N |
Properties
| Appearance | Oily Matter |
| Melting Point | 120-122°C |
Reference Reading
1. TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345
Y Koguchi, Y Asai, S Suzuki, M Nishio, N Yanaka, K Omori, T Ohnuki, S Komatsubara J Antibiot (Tokyo). 1998 Feb;51(2):107-11. doi: 10.7164/antibiotics.51.107.
Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phenethylcarbamate by spectroscopic analyses. This compound enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Taxonomy of the producing strain is also described.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
