TMC-52A
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| Category | Bioactive by-products |
| Catalog number | BBF-02524 |
| CAS | |
| Molecular Weight | 422.5 |
| Molecular Formula | C20H30N4O6 |
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Description
TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM.
Specification
| Synonyms | TMC-52 A |
| IUPAC Name | 3-[[(2S)-1-[3-(4-aminobutylamino)propylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]oxirane-2-carboxylic acid |
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)NCCCNCCCCN)NC(=O)C2C(O2)C(=O)O)O |
| InChI | InChI=1S/C20H30N4O6/c21-8-1-2-9-22-10-3-11-23-18(26)15(12-13-4-6-14(25)7-5-13)24-19(27)16-17(30-16)20(28)29/h4-7,15-17,22,25H,1-3,8-12,21H2,(H,23,26)(H,24,27)(H,28,29)/t15-,16?,17?/m0/s1 |
| InChI Key | PRCZPOBZJVCPKL-GTPINHCMSA-N |
Reference Reading
1. TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp
K Isshiki, M Nishio, N Sakurai, T Uchida, T Okuda, S Komatsubara J Antibiot (Tokyo). 1998 Jul;51(7):629-34. doi: 10.7164/antibiotics.51.629.
New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 values of 13 nM, 10nM, 10nM, and 6nM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
