TMC-69
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| Category | Mycotoxins |
| Catalog number | BBF-02529 |
| CAS | |
| Molecular Weight | 421.5 |
| Molecular Formula | C26H31NO4 |
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Description
TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity.
Specification
| Synonyms | TMC 69 |
| IUPAC Name | 1,4-dihydroxy-3-[(2R,3R,5Z)-3-methyl-5-[(2E,4E)-6-methylocta-2,4-dienylidene]oxan-2-yl]-5-phenylpyridin-2-one |
| Canonical SMILES | CCC(C)C=CC=CC=C1CC(C(OC1)C2=C(C(=CN(C2=O)O)C3=CC=CC=C3)O)C |
| InChI | InChI=1S/C26H31NO4/c1-4-18(2)11-7-5-8-12-20-15-19(3)25(31-17-20)23-24(28)22(16-27(30)26(23)29)21-13-9-6-10-14-21/h5-14,16,18-19,25,28,30H,4,15,17H2,1-3H3/b8-5+,11-7+,20-12-/t18?,19-,25-/m1/s1 |
| InChI Key | IXMWFEZJSGIEGP-OGFVGMJFSA-N |
Properties
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
Reference Reading
1. TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium sp. TC1068. Taxonomy, fermentation and biological activities
N Hirano, J Kohno, S Tsunoda, M Nishio, N Kishi, T Okuda, K Kawano, S Komatsubara, N Nakanishi J Antibiot (Tokyo). 2001 May;54(5):421-7. doi: 10.7164/antibiotics.54.421.
A new antibiotic designated TMC-69 has been isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. TMC-69 exhibited moderate in vitro cytotoxic activity. TMC-69-6H, a derivative of TMC-69 prepared by hydrogenation, possessed more potent in vitro cytotoxicity than TMC-69, and exhibited in vivo antitumor activity against murine P388 leukemia and B16 melanoma. TMC-69-6H was found to specifically inhibit Cdc25A and B phosphatases.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
