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TPU-0031-A

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TPU-0031-A
Category Antibiotics
Catalog number BBF-02550
CAS
Molecular Weight 598.6
Molecular Formula C30H34N2O11

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

TPU-0031-A is an antibiotic of the novobiocin group produced by Streptomyces sp. TP-A0556. It shows antibiotic activity against Gram-positive and -negative bacteria.

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IUPAC Name [(3S,4R,5S,6S)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate
Canonical SMILES CC(=CCC1=C(C=CC(=C1)C(=O)NC2=C(C3=C(C=C(C=C3)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O)OC2=O)O)O)C
InChI InChI=1S/C30H34N2O11/c1-14(2)6-7-15-12-16(8-11-19(15)33)26(36)32-21-22(34)18-10-9-17(13-20(18)41-27(21)37)40-28-23(35)24(42-29(31)38)25(39-5)30(3,4)43-28/h6,8-13,23-25,28,33-35H,7H2,1-5H3,(H2,31,38)(H,32,36)/t23-,24+,25-,28-/m0/s1
InChI Key SRAAUSFKQABSHS-GIBNYFNHSA-N
Appearance Solid Powder
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria
Melting Point 124-126°C
1. TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556
T Sasaki, Y Igarashi, N Saito, T Furumai J Antibiot (Tokyo). 2001 May;54(5):441-7. doi: 10.7164/antibiotics.54.441.
Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5"-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.

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