U-56407
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| Category | Antibiotics |
| Catalog number | BBF-01570 |
| CAS | 87695-80-5 |
| Molecular Weight | 520.6 |
| Molecular Formula | C29H32N2O7 |
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Description
U-56407 is an antibiotic isolated from fermentations of Streptomyces hagronensis (strain 360). It is effective in vitro against Gram-positive bacteria but not Gram-negative organisms.
Specification
| Synonyms | U 56407; 2,4,6-Decatrienamide, N-(5-hydroxy-5-(7-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-7-oxo-1,3,5-heptatrienyl)-2-oxo-7-oxabicyclo(4.1.0)hept-3-en-3-yl)-9-methyl- |
| IUPAC Name | (2E,4E,6E)-N-[5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-9-methyldeca-2,4,6-trienamide |
| Canonical SMILES | CC(C)CC=CC=CC=CC(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O |
| InChI | InChI=1S/C29H32N2O7/c1-19(2)12-8-4-3-5-9-13-23(34)30-20-18-29(37,28-27(38-28)26(20)36)17-11-7-6-10-14-24(35)31-25-21(32)15-16-22(25)33/h3-11,13-14,17-19,27-28,32,37H,12,15-16H2,1-2H3,(H,30,34)(H,31,35)/b5-3+,7-6+,8-4+,13-9+,14-10+,17-11+ |
| InChI Key | GLLPHENDWDLKRH-GXCWGJJBSA-N |
Properties
| Appearance | Bright Yellow Crystalline |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Melting Point | 150°C |
Reference Reading
1. U-56,407, a new antibiotic related to asukamycin: isolation and characterization
T F Brodasky, D W Stroman, A Dietz, S Mizsak J Antibiot (Tokyo). 1983 Aug;36(8):950-6. doi: 10.7164/antibiotics.36.950.
U-56,407, a bright yellow, crystalline antibiotic was isolated from fermentations of Streptomyces hagronensis (strain 360). This antibiotic was extracted from fermentation broths with halogenated hydrocarbons and purified by silica gel chromatography and crystallization. U-56,407 is active in vitro against Gram-positive bacteria but not Gram-negative organisms. It failed to demonstrate in vivo activity in experimentally infected mice. Physical-chemical characterization of U-56,407 supports a molecular formula of C29H32N2O7 and a structure related to the antibiotic asukamycin.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
