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U-68204

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Category Bioactive by-products
Catalog number BBF-01577
CAS 98352-22-8
Molecular Weight 267.35
Molecular Formula C13H17NO3S

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

U-68204 is a thiolactone-containing metabolite produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). It exhibited mild antibacterial activity with CD50 of 50mg/kg for inhibition of bacillus influenzae.

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IUPAC Name 2-[5-ethyl-4-hydroxy-5-[(1E)-2-methylbuta-1,3-dienyl]-2-oxothiophen-3-yl]acetamide
Canonical SMILES CCC1(C(=C(C(=O)S1)CC(=O)N)O)C=C(C)C=C
InChI InChI=1S/C13H17NO3S/c1-4-8(3)7-13(5-2)11(16)9(6-10(14)15)12(17)18-13/h4,7,16H,1,5-6H2,2-3H3,(H2,14,15)/b8-7+
InChI Key UABLTRHPBMADHP-BQYQJAHWSA-N
Appearance Pale Yellow Crystal
Melting Point 99-103°C
1. Isolation and structure of antibiotic U-68,204, a new thiolactone
L A Dolak, T M Castle, S E Truesdell, O K Sebek J Antibiot (Tokyo). 1986 Jan;39(1):26-31. doi: 10.7164/antibiotics.39.26.
A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. On the basis of these data, the antibiotic was identified as the 10-carboxamide of thiotetromycin.

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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