U-68204
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| Category | Bioactive by-products |
| Catalog number | BBF-01577 |
| CAS | 98352-22-8 |
| Molecular Weight | 267.35 |
| Molecular Formula | C13H17NO3S |
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Description
U-68204 is a thiolactone-containing metabolite produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). It exhibited mild antibacterial activity with CD50 of 50mg/kg for inhibition of bacillus influenzae.
Specification
| IUPAC Name | 2-[5-ethyl-4-hydroxy-5-[(1E)-2-methylbuta-1,3-dienyl]-2-oxothiophen-3-yl]acetamide |
| Canonical SMILES | CCC1(C(=C(C(=O)S1)CC(=O)N)O)C=C(C)C=C |
| InChI | InChI=1S/C13H17NO3S/c1-4-8(3)7-13(5-2)11(16)9(6-10(14)15)12(17)18-13/h4,7,16H,1,5-6H2,2-3H3,(H2,14,15)/b8-7+ |
| InChI Key | UABLTRHPBMADHP-BQYQJAHWSA-N |
Properties
| Appearance | Pale Yellow Crystal |
| Melting Point | 99-103°C |
Reference Reading
1. Isolation and structure of antibiotic U-68,204, a new thiolactone
L A Dolak, T M Castle, S E Truesdell, O K Sebek J Antibiot (Tokyo). 1986 Jan;39(1):26-31. doi: 10.7164/antibiotics.39.26.
A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. On the basis of these data, the antibiotic was identified as the 10-carboxamide of thiotetromycin.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
