Get A Quote

UCT4B

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

UCT4B
Category Antibiotics
Catalog number BBF-01593
CAS 143200-52-6
Molecular Weight 380.4
Molecular Formula C20H28O7

Online Inquiry

Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

UCT4B is an antitumor antibiotic produced by Streptomyces sp. It exhibits topoisomerase II mediated DNA cleavage activity. It suppresses gram-positive bacteria and Klebsiella pneumoniae with MIC of 4.1 and 2.1 μg/mL, respectively.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms UCT 4B
IUPAC Name 2-[2-[1-hydroxy-2-[3-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-4-oxo-3,7,8,8a-tetrahydro-2H-naphthalen-1-yl]ethyl]oxiran-2-yl]-2-oxoacetaldehyde
Canonical SMILES CC1C(C(=O)C2(C(C1(C)CC(C3(CO3)C(=O)C=O)O)CCC=C2CO)C)O
InChI InChI=1S/C20H28O7/c1-11-16(25)17(26)19(3)12(8-21)5-4-6-13(19)18(11,2)7-14(23)20(10-27-20)15(24)9-22/h5,9,11,13-14,16,21,23,25H,4,6-8,10H2,1-3H3
InChI Key MLIJBZORKJUODY-UHFFFAOYSA-N
Antibiotic Activity Spectrum Gram-positive bacteria; neoplastics (Tumor)
Melting Point 162-172°C
1. Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification
S Kawada, Y Yamashita, K Ochiai, K Ando, T Iwasaki, T Takiguchi, H Nakano J Antibiot (Tokyo). 1995 Mar;48(3):211-6. doi: 10.7164/antibiotics.48.211.
Terpentecin and UCT4B are new family of antitumor antibiotics with topoisomerase II mediated DNA cleavage activity. Based on the taxonomic studies, the producing strain S-464 was identified as Streptomyces sp. This strain is different from Kitasatosporia griseola which had been identified as the terpentecin-producing strain in 1988. Fermentation studies showed that natural nitrogen sources supported higher titer of terpentecin, and the synthetic medium with inorganic nitrogen sources supported selective production of UCT4B. An improved isolation method was developed for the large scale purification of terpentecin.

Bio Calculators

Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

Recently viewed products

Online Inquiry

Copyright © 2025 BOC Sciences. All rights reserved.

cartIcon
Inquiry Basket