UCT4B
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| Category | Antibiotics |
| Catalog number | BBF-01593 |
| CAS | 143200-52-6 |
| Molecular Weight | 380.4 |
| Molecular Formula | C20H28O7 |
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Description
UCT4B is an antitumor antibiotic produced by Streptomyces sp. It exhibits topoisomerase II mediated DNA cleavage activity. It suppresses gram-positive bacteria and Klebsiella pneumoniae with MIC of 4.1 and 2.1 μg/mL, respectively.
Specification
| Synonyms | UCT 4B |
| IUPAC Name | 2-[2-[1-hydroxy-2-[3-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-4-oxo-3,7,8,8a-tetrahydro-2H-naphthalen-1-yl]ethyl]oxiran-2-yl]-2-oxoacetaldehyde |
| Canonical SMILES | CC1C(C(=O)C2(C(C1(C)CC(C3(CO3)C(=O)C=O)O)CCC=C2CO)C)O |
| InChI | InChI=1S/C20H28O7/c1-11-16(25)17(26)19(3)12(8-21)5-4-6-13(19)18(11,2)7-14(23)20(10-27-20)15(24)9-22/h5,9,11,13-14,16,21,23,25H,4,6-8,10H2,1-3H3 |
| InChI Key | MLIJBZORKJUODY-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; neoplastics (Tumor) |
| Melting Point | 162-172°C |
Reference Reading
1. Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification
S Kawada, Y Yamashita, K Ochiai, K Ando, T Iwasaki, T Takiguchi, H Nakano J Antibiot (Tokyo). 1995 Mar;48(3):211-6. doi: 10.7164/antibiotics.48.211.
Terpentecin and UCT4B are new family of antitumor antibiotics with topoisomerase II mediated DNA cleavage activity. Based on the taxonomic studies, the producing strain S-464 was identified as Streptomyces sp. This strain is different from Kitasatosporia griseola which had been identified as the terpentecin-producing strain in 1988. Fermentation studies showed that natural nitrogen sources supported higher titer of terpentecin, and the synthetic medium with inorganic nitrogen sources supported selective production of UCT4B. An improved isolation method was developed for the large scale purification of terpentecin.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
